Radixin

RDX
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1GC6, 1GC7, 1J19, 2D10, 2D11, 2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY
المعهدات
الأسماء المستعارة	RDX, DFNB24, radixin
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 179410 MGI: MGI:97887 HomoloGene: 37707 GeneCards: 5962
فهم الوجود الجيني
الوظيفة الجزيئية	• protein homodimerization activity; • protein domain specific binding; • ATPase binding; • protein kinase A binding; • cytoskeletal protein binding; • ‏GO:0001948 ربط بروتيني; • actin binding; • RNA binding; • cadherin binding;
المكونات الخلوية	• سيتوبلازم; • غشاء; • focal adhesion; • filopodium; • ruffle; • ميالين; • غشاء خلوي; • apical part of cell; • stereocilium; • زغيبة; • apical plasma membrane; • cortical actin cytoskeleton; • الانشقاق الثلم; • extracellular exosome; • هيكل خلوي; • cell periphery; • lamellipodium; • midbody; • نبيب مستعرض; • cell tip; • خارج خلوي; • إسقاط خلية;
العمليات الحيوية	• regulation of cell size; • establishment of endothelial barrier; • microvillus assembly; • regulation of organelle assembly; • establishment of protein localization; • positive regulation of cell migration; • regulation of GTPase activity; • positive regulation of G1/S transition of mitotic cell cycle; • negative regulation of homotypic cell-cell adhesion; • regulation of actin filament bundle assembly; • positive regulation of gene expression; • negative regulation of GTPase activity; • negative regulation of adherens junction organization; • apical protein localization; • actin filament capping; • cellular response to thyroid hormone stimulus; • regulation of cell shape; • protein kinase A signaling; • regulation of ruffle assembly; • positive regulation of protein localization to early endosome; • positive regulation of early endosome to late endosome transport; • negative regulation of cell size; • regulation of Rap protein signal transduction; • cellular response to platelet-derived growth factor stimulus; • barbed-end actin filament capping; • protein localization to plasma membrane; • positive regulation of cellular protein catabolic process;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P35241; E9PNV3
	P26043
	‏NM_001260492، ‏NM_001260493، ‏NM_001260494، ‏NM_001260495، ‏NM_001260496 NM_002906، ‏NM_001260492، ‏NM_001260493، ‏NM_001260494، ‏NM_001260495، ‏NM_001260496
	‏NM_001104617، ‏NM_009041 NM_001104616، ‏NM_001104617، ‏NM_009041
	‏NP_001247422، ‏NP_001247423، ‏NP_001247424، ‏NP_001247425، ‏NP_002897 NP_001247421، ‏NP_001247422، ‏NP_001247423، ‏NP_001247424، ‏NP_001247425، ‏NP_002897
	‏NP_001098087، ‏NP_033067 NP_001098086، ‏NP_001098087، ‏NP_033067
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

Radixin‏ (Radixin) هوَ بروتين يُشَفر بواسطة جين Radixin في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (June 1993). "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes". Genomics. 16 (1): 199–206. doi:10.1006/geno.1993.1159. PMID 8486357.
↑ "Entrez Gene: RDX radixin". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Khan SY, Ahmed ZM, Shabbir MI, Kitajiri S, Kalsoom S, Tasneem S, Shayiq S, Ramesh A, Srisailpathy S, Khan SN, Smith RJ, Riazuddin S, Friedman TB, Riazuddin S (April 2007). "Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus". Hum Mutat. 28 (5): 417–23. doi:10.1002/humu.20469. PMID 17226784.

قراءة متعمقة

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Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein". J. Biol. Chem. 272 (37): 23371–5. doi:10.1074/jbc.272.37.23371. PMID 9287351.
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Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S, Tsukita S (1998). "Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association". J. Cell Biol. 140 (3): 647–57. doi:10.1083/jcb.140.3.647. PMC 2140160. PMID 9456324.
Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (1998). "Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040.
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Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y (1998). "Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl". Oncogene. 16 (25): 3279–84. doi:10.1038/sj.onc.1201874. PMID 9681826.
Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A (2000). "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nat. Cell Biol. 2 (5): 281–7. doi:10.1038/35010550. PMID 10806479.
Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
Hamada K, Shimizu T, Matsui T, Tsukita S, Tsukita S, Hakoshima T (2001). "Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2". Acta Crystallogr. D. 57 (Pt 6): 891–2. doi:10.1107/S0907444901005716. PMID 11375520.
Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, Tsukita S (2002). "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes". Nat. Genet. 31 (3): 320–5. doi:10.1038/ng905. PMID 12068294.
Dickson TC, Mintz CD, Benson DL, Salton SR (2002). "Functional binding interaction identified between the axonal CAM L1 and members of the ERM family". J. Cell Biol. 157 (7): 1105–12. doi:10.1083/jcb.200111076. PMC 2173555. PMID 12070130.
Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, Gonzalez-Agosti C, Ramesh V (2003). "The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton". J. Biol. Chem. 277 (46): 44180–6. doi:10.1074/jbc.M207211200. PMID 12226091.