• tumor necrosis factor-mediated signaling pathway • protein polyubiquitination • T cell receptor signaling pathway • positive regulation of canonical Wnt signaling pathway • anaphase-promoting complex-dependent catabolic process • regulation of proteasomal protein catabolic process • regulation of G1/S transition of mitotic cell cycle • regulation of mRNA stability • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • antigen processing and presentation of exogenous antigen • regulation of cellular amino acid metabolic process • NIK/NF-kappaB signaling • Fc-epsilon receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • MAPK cascade • stimulatory C-type lectin receptor signaling pathway • positive regulation of endopeptidase activity • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • نقل عبر الغشاء • regulation of transcription from RNA polymerase II promoter in response to hypoxia • تعديل ما بعد الترجمة • regulation of hematopoietic stem cell differentiation • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition
PSME1 (Proteasome activator subunit 1) هوَ بروتين يُشَفر بواسطة جين PSME1 في الإنسان.
الوظيفة
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
الأهمية السريرية
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
المراجع
^Honoré B, Leffers H, Madsen P, Celis JE (Feb 1994). "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111". Eur J Biochem. 218 (2): 421–30. doi:10.1111/j.1432-1033.1993.tb18392.x. PMID 8269930.
^"Entrez Gene: PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)". مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Sijts A, Sun Y, Janek K, Kral S, Paschen A, Schadendorf D, Kloetzel PM (2002). "The role of the proteasome activator PA28 in MHC class I antigen processing". Mol. Immunol. 39 (3–4): 165–9. doi:10.1016/S0161-5890(02)00099-8. PMID 12200048.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1". Cell. 114 (3): 281–3. doi:10.1016/S0092-8674(03)00602-0. PMID 12914693.
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD (1995). "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome". FEBS Lett. 366 (1): 37–42. doi:10.1016/0014-5793(95)00492-R. PMID 7789512.
Realini C, Dubiel W, Pratt G, Ferrell K, Rechsteiner M (1994). "Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease". J. Biol. Chem. 269 (32): 20727–32. PMID 8051173.
Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi:10.1074/jbc.271.30.18237. PMID 8663520.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8. doi:10.1074/jbc.272.13.8145. PMID 9079628.
Soza A, Knuehl C, Groettrup M, Henklein P, Tanaka K, Kloetzel PM (1997). "Expression and subcellular localization of mouse 20S proteasome activator complex PA28". FEBS Lett. 413 (1): 27–34. doi:10.1016/S0014-5793(97)00864-8. PMID 9287111.
McCusker D, Jones T, Sheer D, Trowsdale J (1998). "Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex". Genomics. 45 (2): 362–7. doi:10.1006/geno.1997.4948. PMID 9344661.
Johnston SC, Whitby FG, Realini C, Rechsteiner M, Hill CP (1998). "The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer". Protein Sci. 6 (11): 2469–73. doi:10.1002/pro.5560061123. PMC 2143584. PMID 9385652.
Wang X, Omura S, Szweda LI, Yang Y, Bérard J, Seminaro J, Wu J (1998). "Rapamycin inhibits proteasome activator expression and proteasome activity". Eur. J. Immunol. 27 (11): 2781–6. doi:10.1002/eji.1830271106. PMID 9394799.
Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP (1998). "Structure of the proteasome activator REGalpha (PA28alpha)". Nature. 390 (6660): 639–43. Bibcode:1997Natur.390..639K. doi:10.1038/37670. PMID 9403698.
Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M (1998). "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes". J. Immunol. 160 (10): 4923–35. PMID 9590240.
Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein". J. Virol. 72 (12): 10251–5. PMC 110608. PMID 9811770.
Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
McCusker D, Wilson M, Trowsdale J (1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics. 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920.
تاريخ النشر:
2020-06-02 13:08:09
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