RAE1

RAE1
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	3MMY, 4OWR
المعهدات
الأسماء المستعارة	RAE1, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1, Gle2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 603343 MGI: MGI:1913929 HomoloGene: 2676 GeneCards: 8480
فهم الوجود الجيني
الوظيفة الجزيئية	• microtubule binding; • RNA binding; • ‏GO:0001948 ربط بروتيني; • ubiquitin binding;
المكونات الخلوية	• سيتوبلازم; • مسام نووي; • نواة; • nuclear envelope; • fibrillar center; • mitotic spindle pole; • spindle pole; • هيكل خلوي; • host cell;
العمليات الحيوية	• cellular response to organic cyclic compound; • viral process; • regulation of mitotic spindle organization; • transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; • RNA export from nucleus; • protein import into nucleus; • دورة الخلية; • انقسام خلوي; • mRNA export from nucleus; • regulation of glycolytic process; • tRNA export from nucleus; • protein sumoylation; • viral transcription; • regulation of gene silencing by miRNA; • intracellular transport of virus; • regulation of cellular response to heat;
	المصادر:Amigo / QuickGO
أورثولوج
	P78406
	Q8C570
	‏NM_001015885، ‏NM_003610، ‏XM_005260582، ‏XM_005260583، ‏XM_011529087، ‏XM_011529088، ‏XM_017028108 XM_011529089، ‏NM_001015885، ‏NM_003610، ‏XM_005260582، ‏XM_005260583، ‏XM_011529087، ‏XM_011529088، ‏XM_017028108
	‏XM_006500023، ‏XM_006500024 NM_175112، ‏XM_006500023، ‏XM_006500024
	‏NP_003601، ‏XP_005260639، ‏XP_005260640، ‏XP_011527389، ‏XP_011527390، ‏XP_011527391، ‏XP_016883597 NP_001015885، ‏NP_003601، ‏XP_005260639، ‏XP_005260640، ‏XP_011527389، ‏XP_011527390، ‏XP_011527391، ‏XP_016883597
	‏XP_006500086، ‏XP_006500087 NP_780321، ‏XP_006500086، ‏XP_006500087
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

RAE1‏ (Ribonucleic acid export 1) هوَ بروتين يُشَفر بواسطة جين RAE1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Bharathi A, Ghosh A, Whalen WA, Yoon JH, Pu R, Dasso M, Dhar R (Dec 1997). "The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA". Gene. 198 (1–2): 251–8. doi:10.1016/S0378-1119(97)00322-3. PMID 9370289.
^ Kraemer D, Blobel G (Sep 1997). "mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm". Proc Natl Acad Sci U S A. 94 (17): 9119–24. Bibcode:1997PNAS...94.9119K. doi:10.1073/pnas.94.17.9119. PMC 23064. PMID 9256445.
↑ "Entrez Gene: RAE1 RAE1 RNA export 1 homolog (S. pombe)". مؤرشف من الأصل فيخمسة ديسمبر 2010.

قراءة متعمقة

Nomura M, Zou Z, Joh T, et al. (1997). "Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain". J. Biochem. 120 (5): 987–95. doi:10.1093/oxfordjournals.jbchem.a021517. PMID 8982867.
Yoon JH, Whalen WA, Bharathi A, et al. (1997). "Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export". Mol. Cell. Biol. 17 (12): 7047–60. PMC 232561. PMID 9372936.
Matsuoka Y, Takagi M, Ban T, et al. (1999). "Identification and characterization of nuclear pore subcomplexes in mitotic extract of human somatic cells". Biochem. Biophys. Res. Commun. 254 (2): 417–23. doi:10.1006/bbrc.1998.9953. PMID 9918853.
Pritchard CE, Fornerod M, Kasper LH, van Deursen JM (1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. 145 (2): 237–54. doi:10.1083/jcb.145.2.237. PMC 2133102. PMID 10209021.
Bachi A, Braun IC, Rodrigues JP, et al. (2000). "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates". RNA. 6 (1): 136–58. doi:10.1017/S1355838200991994. PMC 1369901. PMID 10668806.
Yoon JH, Love DC, Guhathakurta A, et al. (2000). "Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export". Mol. Cell. Biol. 20 (23): 8767–82. doi:10.1128/MCB.20.23.8767-8782.2000. PMC 86506. PMID 11073978.
Sabri N, Visa N (2000). "The Ct-RAE1 protein interacts with Balbiani ring RNP particles at the nuclear pore". RNA. 6 (11): 1597–609. doi:10.1017/S1355838200001138. PMC 1370029. PMID 11105759.
Wang X, Babu JR, Harden JM, et al. (2001). "The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins". J. Biol. Chem. 276 (28): 26559–67. doi:10.1074/jbc.M101083200. PMID 11352911.
O'Callaghan CA, Cerwenka A, Willcox BE, et al. (2001). "Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60". Immunity. 15 (2): 201–11. doi:10.1016/S1074-7613(01)00187-X. PMID 11520456.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Kraemer D, Dresbach T, Drenckhahn D (2002). "Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons". Eur. J. Cell Biol. 80 (12): 733–40. doi:10.1078/0171-9335-00216. PMID 11831386.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Faria PA, Chakraborty P, Levay A, et al. (2005). "VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway". Mol. Cell. 17 (1): 93–102. doi:10.1016/j.molcel.2004.11.023. PMID 15629720.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Blower MD, Nachury M, Heald R, Weis K (2005). "A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly". Cell. 121 (2): 223–34. doi:10.1016/j.cell.2005.02.016. PMID 15851029.
Wong RW, Blobel G, Coutavas E (2007). "Rae1 interaction with NuMA is required for bipolar spindle formation". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19783–7. Bibcode:2006PNAS..10319783W. doi:10.1073/pnas.0609582104. PMC 1750899. PMID 17172455.