GABPA

GABPA
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1AWC, 1SXD, 2JUO
المعهدات
الأسماء المستعارة	GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07, GA binding protein transcription factor alpha subunit, GA binding protein transcription factor subunit alpha
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600609 MGI: MGI:95610 HomoloGene: 1543 GeneCards: 2551
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إذا إي; • sequence-specific DNA binding; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • ‏GO:0001077، ‏GO:0001212، ‏GO:0001213، ‏GO:0001211، ‏GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • ‏GO:0001105 transcription coactivator activity; • chromatin binding; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • ‏GO:0001948 ربط بروتيني; • protein heterodimerization activity; • activating transcription factor binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
المكونات الخلوية	• بلازم نووي; • nuclear chromatin; • نواة;
العمليات الحيوية	• تمايز خلوي; • ضبط نسخ الدنا; • ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني; • mitochondrion organization; • in utero embryonic development; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of megakaryocyte differentiation; • نسخ الدنا; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • transcription from RNA polymerase II promoter; • positive regulation of gene expression; • cellular response to dopamine; • blastocyst formation;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q06546; Q8IYS3
	Q00422
	‏NM_001197297، ‏NM_002040، ‏XM_005260938، ‏XM_011529520، ‏XM_017028313، ‏XM_024452062 XM_011529521، ‏NM_001197297، ‏NM_002040، ‏XM_005260938، ‏XM_011529520، ‏XM_017028313، ‏XM_024452062
	‏XM_006522905، ‏XM_006522906، ‏XM_006522907، ‏XR_876129، ‏XM_017316875، ‏XM_017316876، ‏XM_030248977 NM_008065، ‏XM_006522905، ‏XM_006522906، ‏XM_006522907، ‏XR_876129، ‏XM_017316875، ‏XM_017316876، ‏XM_030248977
	‏NP_002031، ‏XP_005260995، ‏XP_011527822، ‏XP_011527823، ‏XP_016883802، ‏XP_024307830 NP_001184226، ‏NP_002031، ‏XP_005260995، ‏XP_011527822، ‏XP_011527823، ‏XP_016883802، ‏XP_024307830; NP_002031.2
	‏XP_006522968، ‏XP_006522969، ‏XP_006522970، ‏XP_017172364، ‏XP_017172365، ‏XP_030104837 NP_032091، ‏XP_006522968، ‏XP_006522969، ‏XP_006522970، ‏XP_017172364، ‏XP_017172365، ‏XP_030104837
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

GABPA‏ (GA binding protein transcription factor subunit alpha) هوَ بروتين يُشَفر بواسطة جين GABPA في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M, Handa H (Mar 1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Molecular and Cellular Biology. 13 (3): 1385–91. PMC 359448. PMID 8441384.

قراءة متعمقة

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Sawada J, Goto M, Watanabe H, Handa H, Yoshida MC (Jan 1995). "Regional mapping of two subunits of transcription factor E4TF1 to human chromosome". Japanese Journal of Cancer Research. 86 (1): 10–2. doi:10.1111/j.1349-7006.1995.tb02981.x. PMID 7737900.
Gugneja S, Virbasius JV, Scarpulla RC (Jan 1995). "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain". Molecular and Cellular Biology. 15 (1): 102–11. PMC 231915. PMID 7799916.
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Sawa C, Goto M, Suzuki F, Watanabe H, Sawada J, Handa H (Dec 1996). "Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation". Nucleic Acids Research. 24 (24): 4954–61. doi:10.1093/nar/24.24.4954. PMC 146336. PMID 9016666.
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Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C (Feb 1998). "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA". Science. 279 (5353): 1037–41. doi:10.1126/science.279.5353.1037. PMID 9461436.
Suzuki F, Goto M, Sawa C, Ito S, Watanabe H, Sawada J, Handa H (Nov 1998). "Functional interactions of transcription factor human GA-binding protein subunits". The Journal of Biological Chemistry. 273 (45): 29302–8. doi:10.1074/jbc.273.45.29302. PMID 9792629.
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Bannert N, Avots A, Baier M, Serfling E, Kurth R (Feb 1999). "GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1541–6. doi:10.1073/pnas.96.4.1541. PMC 15509. PMID 9990060.
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Guo A, Nie F, Wong-Riley M (Feb 2000). "Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system". The Journal of Comparative Neurology. 417 (2): 221–32. doi:10.1002/(SICI)1096-9861(20000207)417:2<221::AID-CNE7>3.0.CO;2-4. PMID 10660899.
Vogel JL, Kristie TM (Feb 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". The EMBO Journal. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337.
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