CAPN10

CAPN10
المعهدات
الأسماء المستعارة	CAPN10, CANP10, NIDDM1, calpain 10
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605286 MGI: MGI:1344392 HomoloGene: 36323 GeneCards: 11132
فهم الوجود الجيني
الوظيفة الجزيئية	• cytoskeletal protein binding; • نشاط الببتيداز; • cysteine-type peptidase activity; • نشاط هيدرولاز; • SNARE binding; • calcium-dependent cysteine-type endopeptidase activity;
المكونات الخلوية	• داخل خلوي; • عصارة خلوية; • غشاء خلوي; • ميتوكندريون; • سيتوبلازم;
العمليات الحيوية	• actin cytoskeleton reorganization; • positive regulation of glucose import; • cellular component disassembly involved in execution phase of apoptosis; • positive regulation of intracellular transport; • positive regulation of type B pancreatic cell apoptotic process; • تحلل بروتيني; • positive regulation of insulin secretion; • cellular response to insulin stimulus; • type B pancreatic cell apoptotic process;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9HC96; H7C251
	Q9ESK3
	‏NM_021251، ‏NM_023083، ‏NM_023084، ‏NM_023085، ‏NM_023086، ‏NM_023087، ‏NM_023088 NM_023089، ‏NM_021251، ‏NM_023083، ‏NM_023084، ‏NM_023085، ‏NM_023086، ‏NM_023087، ‏NM_023088
	NM_011796
	‏NP_075573 NP_075571، ‏NP_075573
	NP_035926
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

CAPN10‏ (Calpain 10) هوَ بروتين يُشَفر بواسطة جين CAPN10 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C (Oct 2000). "A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance". J Clin Invest. 106 (7): R69–73. doi:10.1172/JCI10665. PMC 387246. PMID 11018080.
^ Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI (Nov 2000). "Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus". Nat Genet. 26 (2): 163–75. doi:10.1038/79876. PMID 11017071.
^ "Entrez Gene: CAPN10 calpain 10". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

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Cox NJ, Hayes MG, Roe CA, et al. (2004). "Linkage of calpainعشرة to type 2 diabetes: the biological rationale". Diabetes. 53 Suppl 1: S19–25. doi:10.2337/diabetes.53.2007.s19. PMID 14749261.
Turner MD, Cassell PG, Hitman GA (2006). "Calpain-10: from genome search to function". Diabetes Metab. Res. Rev. 21 (6): 505–14. doi:10.1002/dmrr.578. PMID 16028216.
Horikawa Y (2007). "Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes". Endocr. J. 53 (5): 567–76. doi:10.1507/endocrj.KR-70. PMID 16873988.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
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Evans JC, Frayling TM, Cassell PG, et al. (2001). "Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom". Am. J. Hum. Genet. 69 (3): 544–52. doi:10.1086/323315. PMC 1235484. PMID 11481585.
Tsai HJ, Sun G, Weeks DE, et al. (2002). "Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association". Am. J. Hum. Genet. 69 (6): 1236–44. doi:10.1086/324646. PMC 1235535. PMID 11704924.
Woollard JR, Rothschild MF (2002). "Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26". Anim. Genet. 32 (6): 393–393. doi:10.1046/j.1365-2052.2001.0781d.x. PMID 11736815.
Xiang K, Fang Q, Zheng T, et al. (2002). "[The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 18 (6): 426–30. PMID 11774208.
Elbein SC, Chu W, Ren Q, et al. (2002). "Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians". J. Clin. Endocrinol. Metab. 87 (2): 650–4. doi:10.1210/jc.87.2.650. PMID 11836299.
Daimon M, Oizumi T, Saitoh T, et al. (2002). "Calpainعشرة gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese". Diabetes Res. Clin. Pract. 56 (2): 147–52. doi:10.1016/S0168-8227(01)00372-2. PMID 11891023.
Fullerton SM, Bartoszewicz A, Ybazeta G, et al. (2002). "Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus". Am. J. Hum. Genet. 70 (5): 1096–106. doi:10.1086/339930. PMC 447588. PMID 11891618.
Hoffstedt J, Rydén M, Löfgren P, et al. (2002). "Polymorphism in the Calpainعشرة gene influences glucose metabolism in human fat cells". Diabetologia. 45 (2): 276–82. doi:10.1007/s00125-001-0732-2. PMID 11935160.
Malecki MT, Moczulski DK, Klupa T, et al. (2002). "Homozygous combination of calpainعشرة gene haplotypes is associated with type 2 diabetes mellitus in a Polish population". Eur. J. Endocrinol. 146 (5): 695–9. doi:10.1530/eje.0.1460695. PMID 11980626.
Sun HX, Zhang KX, Du WN, et al. (2002). "Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China". Biomed. Environ. Sci. 15 (1): 75–82. PMID 12046551.
Haddad L, Evans JC, Gharani N, et al. (2002). "Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome". J. Clin. Endocrinol. Metab. 87 (6): 2606–10. doi:10.1210/jc.87.6.2606. PMID 12050223.