GDF7

GDF7
المعهدات
الأسماء المستعارة	GDF7, BMP12, growth differentiation factor 7
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604651 MGI: MGI:95690 HomoloGene: 32177 GeneCards: 151449
فهم الوجود الجيني
الوظيفة الجزيئية	• cytokine activity; • protein homodimerization activity; • ‏GO:0001948 ربط بروتيني; • transforming growth factor beta receptor binding; • growth factor activity;
المكونات الخلوية	• منطقة خارج الخلية; • خارج خلوي;
العمليات الحيوية	• regulation of apoptotic process; • pathway-restricted SMAD protein phosphorylation; • cell fate commitment; • epithelial cell differentiation; • regulation of MAPK cascade; • SMAD protein signal transduction; • spinal cord association neuron differentiation; • cell development; • positive regulation of tendon cell differentiation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • roof plate formation; • BMP signaling pathway; • axon guidance; • reproductive structure development; • positive regulation of transcription, DNA-templated; • forebrain morphogenesis; • gland morphogenesis; • positive regulation of gene expression; • positive regulation of neuron differentiation; • neural tube development; • branching morphogenesis of an epithelial tube; • midbrain development; • activin receptor signaling pathway; • morphogenesis of an epithelial fold; • regulation of receptor activity;
	المصادر:Amigo / QuickGO
أورثولوج
	Q7Z4P5
	P43029
	NM_182828
	‏NM_001312876 NM_013527، ‏NM_001312876
	NP_878248
	‏NP_038555 NP_001299805، ‏NP_038555
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

GDF7‏ (Growth differentiation factor 7) هوَ بروتين يُشَفر بواسطة جين GDF7 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

↑ Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
^ Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA. 102 (20): 7192–7. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.

قراءة متعمقة

Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Davidson AJ, Postlethwait JH, Yan YL, et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6,سبعة subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976.
Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons". Neuron. 38 (3): 389–401. doi:10.1016/S0896-6273(03)00254-X. PMID 12741987.
Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.