TRA2B

TRA2B
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2CQC, 2KXN, 2RRA, 2RRB
المعهدات
الأسماء المستعارة	TRA2B, Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B, transformer 2 beta homolog (Drosophila), transformer 2 beta homolog
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602719 MGI: MGI:106016 HomoloGene: 20965 GeneCards: 6434
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط حمض نووي; • mRNA binding; • ‏GO:0001948 ربط بروتيني; • poly-purine tract binding; • RNA binding; • protein domain specific binding; • pre-mRNA binding; • identical protein binding;
المكونات الخلوية	• نواة; • nuclear inner membrane; • بلازم نووي; • spliceosomal complex; • ribonucleoprotein;
العمليات الحيوية	• RNA splicing, via transesterification reactions; • تضفير الآر حتى إيه; • cerebral cortex regionalization; • mRNA processing; • negative regulation of mRNA splicing, via spliceosome; • embryonic brain development; • mRNA splicing, via spliceosome; • positive regulation of mRNA splicing, via spliceosome; • regulation of alternative mRNA splicing, via spliceosome; • regulation of RNA splicing; • protein oligomerization; • cellular response to glucose stimulus;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P62995
	P62996
	‏NM_004593، ‏XM_005247703، ‏XM_024453706 NM_001243879، ‏NM_004593، ‏XM_005247703، ‏XM_024453706
	‏XM_017316896، ‏NM_001330554، ‏NM_001330555 NM_009186، ‏XM_017316896، ‏NM_001330554، ‏NM_001330555
	‏NP_004584، ‏XP_005247760، ‏XP_024309474 NP_001230808، ‏NP_004584، ‏XP_005247760، ‏XP_024309474
	‏NP_001317484، ‏NP_033212، ‏XP_017172385 NP_001317483، ‏NP_001317484، ‏NP_033212، ‏XP_017172385
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

TRA2B‏ (Transformer 2 beta homolog) هوَ بروتين يُشَفر بواسطة جين TRA2B في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: SFRS10 splicing factor, arginine/serine-richعشرة (transformer 2 homolog, Drosophila)". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Nayler O, Cap C, Stamm S (October 1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.

قراءة متعمقة

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Beil B, Screaton G, Stamm S (1997). "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing". DNA Cell Biol. 16 (6): 679–90. doi:10.1089/dna.1997.16.679. PMID 9212162.
Imai Y, Matsuo N, Ogawa S, et al. (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Res. Mol. Brain Res. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
Tacke R, Tohyama M, Ogawa S, Manley JL (1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–48. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399.
Nayler O, Cap C, Stamm S (1998). "Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform". Genomics. 53 (2): 191–202. doi:10.1006/geno.1998.5471. PMID 9790768.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
Lai MC, Lin RI, Huang SY, et al. (2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". J. Biol. Chem. 275 (11): 7950–7. doi:10.1074/jbc.275.11.7950. PMID 10713112.
Venables JP, Elliott DJ, Makarova OV, et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet. 9 (5): 685–94. doi:10.1093/hmg/9.5.685. PMID 10749975.
Helmken C, Wirth B (2001). "Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy". Hum. Genet. 107 (6): 554–8. doi:10.1007/s004390000409. PMID 11153908.
Young PJ, DiDonato CJ, Hu D, et al. (2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exonسبعة inclusion is facilitated by a direct interaction with hTra2 beta 1". Hum. Mol. Genet. 11 (5): 577–87. doi:10.1093/hmg/11.5.577. PMID 11875052.
Hofmann Y, Wirth B (2003). "hnRNP-G promotes exonسبعة inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. PMID 12165565.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochim. Biophys. Acta. 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
El Yazidi-Belkoura I, Adriaenssens E, Dollé L, et al. (2003). "Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells". J. Biol. Chem. 278 (19): 16952–6. doi:10.1074/jbc.M300631200. PMID 12604596.
Jiang Z, Tang H, Havlioglu N, et al. (2003). "Mutations in tau gene exonعشرة associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta". J. Biol. Chem. 278 (21): 18997–9007. doi:10.1074/jbc.M301800200. PMC 2140226. PMID 12649279.
Chen X, Guo L, Lin W, Xu P (2004). "Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern". Cell Biol. Int. 27 (6): 491–6. doi:10.1016/S1065-6995(03)00072-6. PMID 12798777.
Helmken C, Hofmann Y, Schoenen F, et al. (2004). "Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1". Hum. Genet. 114 (1): 11–21. doi:10.1007/s00439-003-1025-2. PMID 14520560.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
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