WNT10B

WNT10B
المعهدات
الأسماء المستعارة	WNT10B, SHFM6, WNT-12, Wnt family member 10B, STHAG8
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 601906 MGI: MGI:108061 HomoloGene: 20721 GeneCards: 7480
فهم الوجود الجيني
الوظيفة الجزيئية	• receptor ligand activity; • ‏GO:0005110 frizzled binding; • receptor binding;
المكونات الخلوية	• منطقة خارج الخلية; • خارج خلوي;
العمليات الحيوية	• cellular response to organic substance; • myoblast differentiation involved in skeletal muscle regeneration; • cellular response to retinoic acid; • cell fate commitment; • negative regulation of fat cell differentiation; • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; • chondrocyte differentiation; • positive regulation of bone mineralization; • أيض الليبيدات; • positive regulation of canonical Wnt signaling pathway; • ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني; • hematopoietic stem cell proliferation; • cellular response to organic cyclic compound; • protein stabilization; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of ossification; • negative regulation of transcription from RNA polymerase II promoter; • bone trabecula formation; • positive regulation of timing of anagen; • regulation of fat cell differentiation; • نمومتعدد الخلايا; • positive regulation of epithelial cell differentiation; • positive regulation of osteoblast differentiation; • fungiform papilla development; • skeletal muscle tissue regeneration; • G2/M transition of mitotic cell cycle; • skeletal muscle fiber development; • cell cycle arrest; • neuron differentiation; • ضبط زيادي للتكاثر الخلوي; • negative regulation of epithelial cell proliferation; • positive regulation of apoptotic process; • regulation of proteasomal ubiquitin-dependent protein catabolic process; • canonical Wnt signaling pathway; • regulation of skeletal muscle tissue development; • positive regulation of G2/M transition of mitotic cell cycle; • smoothened signaling pathway; • cellular response to parathyroid hormone stimulus; • regulation of protein metabolic process; • sensory perception of taste; • cellular response to cAMP; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • Wnt signaling pathway; • regulation of receptor activity; • negative regulation of cold-induced thermogenesis;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O00744
	P48614
	‏NM_003394، ‏XM_011538722، ‏XM_017019919، ‏XM_024449179 XM_011538724، ‏NM_003394، ‏XM_011538722، ‏XM_017019919، ‏XM_024449179
	‏XM_006520891، ‏XM_006520892، ‏XM_006520893 NM_011718، ‏XM_006520891، ‏XM_006520892، ‏XM_006520893
	‏XP_011537024، ‏XP_011537026، ‏XP_016875408، ‏XP_024304947 NP_003385، ‏XP_011537024، ‏XP_011537026، ‏XP_016875408، ‏XP_024304947
	‏XP_006520954، ‏XP_006520955، ‏XP_006520956 NP_035848، ‏XP_006520954، ‏XP_006520955، ‏XP_006520956
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

WNT10B‏ (Wnt family member 10B) هوَ بروتين يُشَفر بواسطة جين WNT10B في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution. 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID 11110906.
^ Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.
↑ "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B". مؤرشف من الأصل في 07 مارس 2010.
^ Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet. 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319.
^ Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene. 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776.
^ Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet. 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937.

قراءة متعمقة

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
Ross SE, Hemati N, Longo KA, et al. (2000). "Inhibition of adipogenesis by Wnt signaling". Science. 289 (5481): 950–3. doi:10.1126/science.289.5481.950. PMID 10937998.
Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92. doi:10.3892/ijo.19.6.1187. PMID 11713588.
Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment international. 28 (5): 429–32. doi:10.1016/S0160-4120(02)00072-7. PMID 12437293.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Christodoulides C, Scarda A, Granzotto M, et al. (2006). "WNT10B mutations in human obesity". Diabetologia. 49 (4): 678–84. doi:10.1007/s00125-006-0144-4. PMC 4304000. PMID 16477437.
Thrasivoulou C, Millar M, Ahmed A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. doi:10.1074/jbc.M112.437913. PMC 3861617. PMID 24158438.