Desmoglein-1

DSG1
المعهدات
الأسماء المستعارة	DSG1, CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1, desmoglein 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 125670 MGI: MGI:2664357 HomoloGene: 1463 GeneCards: 1828
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط أيون الكالسيوم; • gamma-catenin binding; • ربط أيون فلزي; • ‏GO:0001948 ربط بروتيني; • toxic substance binding;
المكونات الخلوية	• مكون تكاملي للغشاء; • عصارة خلوية; • lateral plasma membrane; • غشاء; • intercellular junction; • غشاء خلوي; • جسيم رابط; • موصل خلوي; • apical plasma membrane; • cytoplasmic side of plasma membrane; • cornified envelope; • ficolin-1-rich granule membrane;
العمليات الحيوية	• calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; • maternal process involved in female pregnancy; • response to progesterone; • protein stabilization; • التصاق الخلايا; • cell-cell junction assembly; • homophilic cell adhesion via plasma membrane adhesion molecules; • keratinization; • neutrophil degranulation; • cornification; • cell-cell adhesion;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q02413
	Q7TSF1
	NM_001942
	‏XM_006525821 NM_181682، ‏XM_006525821
	NP_001933
	‏XP_006525884 NP_859010، ‏XP_006525884
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

Desmoglein-1‏ (Desmoglein 1) هوَ بروتين يُشَفر بواسطة جين Desmoglein-1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: DSG1 desmoglein 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (July 1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): 640–5. doi:10.1016/0888-7543(91)90446-L. PMID 1889810.
^ Beigi, Pooya Khan Mohammad (2018). (باللغة الإنجليزية). Springer, Cham. صفحات 3–10. doi:10.1007/978-3-319-67759-0_1. ISBN . مؤرشف من الأصل في 08 يونيو2018.

قراءة متعمقة

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Wheeler GN, Parker AE, Thomas CL, Ataliotis P, Poynter D, Arnemann J, Rutman AJ, Pidsley SC, Watt FM, Rees DA (June 1991). "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules". Proceedings of the National Academy of Sciences of the United States of America. 88 (11): 4796–800. doi:10.1073/pnas.88.11.4796. PMC 51753. PMID 1711210.
Amagai M, Klaus-Kovtun V, Stanley JR (November 1991). "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion". Cell. 67 (5): 869–77. doi:10.1016/0092-8674(91)90360-B. PMID 1720352.
Martínez RD (1992). "[Characterization of the desmoglein in renal cells in culture]" [Characterization of the desmoglein in renal cells in culture]. Revista Alergia Mexico (باللغة الإسبانية). 38 (2): 59–64. PMID 1754823.
Nilles LA, Parry DA, Powers EE, Angst BD, Wagner RM, Green KJ (August 1991). "Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome". Journal of Cell Science. 99 ( Pt 4) (4): 809–21. PMID 1770008.
Roh JY, Stanley JR (May 1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment". The Journal of Investigative Dermatology. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346.
Simrak D, Cowley CM, Buxton RS, Arnemann J (January 1995). "Tandem arrangement of the closely linked desmoglein genes on human chromosome 18". Genomics. 25 (2): 591–4. doi:10.1016/0888-7543(95)80067-V. PMID 7790000.
Wang Y, Amagai M, Minoshima S, Sakai K, Green KJ, Nishikawa T, Shimizu N (April 1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics. 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID 8034325.
Schäfer S, Koch PJ, Franke WW (April 1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Experimental Cell Research. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788.
Adams MJ, Reichel MB, King IA, Marsden MD, Greenwood MD, Thirlwell H, Arnemann J, Buxton RS, Ali RR (January 1998). "Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens". The Biochemical Journal. 329 ( Pt 1) (Pt 1): 165–74. PMC 1219028. PMID 9405290.
Marcozzi C, Burdett ID, Buxton RS, Magee AI (February 1998). "Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion". Journal of Cell Science. 111 ( Pt 4) (4): 495–509. PMID 9443898.
Smith EA, Fuchs E (June 1998). "Defining the interactions between intermediate filaments and desmosomes". The Journal of Cell Biology. 141 (5): 1229–41. doi:10.1083/jcb.141.5.1229. PMC 2137181. PMID 9606214.
Rickman L, Simrak D, Stevens HP, Hunt DM, King IA, Bryant SP, Eady RA, Leigh IM, Arnemann J, Magee AI, Kelsell DP, Buxton RS (June 1999). "N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma". Human Molecular Genetics. 8 (6): 971–6. doi:10.1093/hmg/8.6.971. PMID 10332028.
Li G, Schaider H, Satyamoorthy K, Hanakawa Y, Hashimoto K, Herlyn M (December 2001). "Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development". Oncogene. 20 (56): 8125–35. doi:10.1038/sj.onc.1205034. PMID 11781826.
Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ (March 2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". The Journal of Biological Chemistry. 277 (12): 10512–22. doi:10.1074/jbc.M108765200. PMID 11790773.
Martel P, Gilbert D, Busson M, Loiseau P, Lepage V, Drouot L, Delaporte E, Prost C, Joly P, Charron D, Tron F (June 2002). "Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus". Genes and Immunity. 3 (4): 205–10. doi:10.1038/sj.gene.6363839. PMID 12058255.
Hanakawa Y, Schechter NM, Lin C, Garza L, Li H, Yamaguchi T, Fudaba Y, Nishifuji K, Sugai M, Amagai M, Stanley JR (July 2002). "Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome". The Journal of Clinical Investigation. 110 (1): 53–60. doi:10.1172/JCI15766. PMC 151035. PMID 12093888.
Hanakawa Y, Amagai M, Shirakata Y, Yahata Y, Tokumaru S, Yamasaki K, Tohyama M, Sayama K, Hashimoto K (December 2002). "Differential effects of desmoglein 1 and desmoglein ثلاثة on desmosome formation". The Journal of Investigative Dermatology. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID 12485422.