MYBPC2

MYBPC2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2E7C, 2EDK, 2EDN
المعهدات
الأسماء المستعارة	MYBPC2, MYBPC, MYBPCF, myosin binding protein C, fast type, fsMyBP-C, myosin binding protein C2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 160793 MGI: MGI:1336170 HomoloGene: 3331 GeneCards: 4606
فهم الوجود الجيني
الوظيفة الجزيئية	• actin binding; • structural constituent of muscle; • ‏GO:0001948 ربط بروتيني; • actin filament binding; • muscle alpha-actinin binding; • structural molecule activity conferring elasticity;
المكونات الخلوية	• myosin filament; • عصارة خلوية; • muscle myosin complex; • Z disc; • M band; • striated muscle thin filament; • ساركومير;
العمليات الحيوية	• التصاق الخلايا; • انقباض عضلي; • muscle filament sliding; • striated muscle contraction; • actin filament organization; • sarcomere organization; • striated muscle myosin thick filament assembly; • skeletal muscle thin filament assembly; • skeletal muscle myosin thick filament assembly; • cardiac muscle fiber development; • cardiac myofibril assembly; • cardiac muscle tissue morphogenesis;
	المصادر:Amigo / QuickGO
أورثولوج
	Q14324
	Q5XKE0
	NM_004533
	‏XM_006540819 NM_146189، ‏XM_006540819
	NP_004524
	‏XP_006540882 NP_666301، ‏XP_006540882
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

MYBPC2‏ (Myosin binding protein C, fast type) هوَ بروتين يُشَفر بواسطة جين MYBPC2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: Myosin binding protein C, fast type". مؤرشف من الأصل في 18 أبريل 2016.

قراءة متعمقة

Luther PK, Bennett PM, Knupp C, Craig R, Padrón R, Harris SP, Patel J, Moss RL (Dec 2008). "Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle". Journal of Molecular Biology. 384 (1): 60–72. doi:10.1016/j.jmb.2008.09.013. PMC 2593797. PMID 18817784.
Hitomi N, Kubo T, Kitaoka H, Hirota T, Hamada T, Hoshikawa E, Hayato K, Okawa M, Kimura A, Doi YL (Sep 2010). "A frameshift deletion mutation in the cardiac myosin-binding protein C gene associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy". Journal of Cardiology. 56 (2): 189–96. doi:10.1016/j.jjcc.2010.04.003. PMID 20605413.
Flashman E, Korkie L, Watkins H, Redwood C, Moolman-Smook JC (Feb 2008). "Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle". FEBS Letters. 582 (3): 434–8. doi:10.1016/j.febslet.2008.01.004. PMID 18201573.
Moolman-Smook J, Flashman E, de Lange W, Li Z, Corfield V, Redwood C, Watkins H (Oct 2002). "Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations". Circulation Research. 91 (8): 704–11. doi:10.1161/01.res.0000036750.81083.83. PMID 12386147.
Weber FE, Vaughan KT, Reinach FC, Fischman DA (Sep 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". European Journal of Biochemistry / FEBS. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.
Guardiani C, Cecconi F, Livi R (Mar 2008). "Computational analysis of folding and mutation properties of C5 domain of myosin binding protein C". Proteins. 70 (4): 1313–22. doi:10.1002/prot.21621. PMID 17876814.
Meurs KM, Kuan M (Mar 2011). "Differential methylation of CpG sites in two isoforms of myosin binding protein C, an important hypertrophic cardiomyopathy gene". Environmental and Molecular Mutagenesis. 52 (2): 161–4. doi:10.1002/em.20596. PMID 20740642.
Welikson RE, Fischman DA (Sep 2002). "The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells". Journal of Cell Science. 115 (Pt 17): 3517–26. PMID 12154082.
Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA (Aug 1997). "Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain". The Journal of Biological Chemistry. 272 (33): 20866–72. doi:10.1074/jbc.272.33.20866. PMID 9252413.