IGFBP2

IGFBP2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2H7T
المعهدات
الأسماء المستعارة	IGFBP2, IBP2, IGF-BP53, insulin like growth factor binding protein 2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 146731 MGI: MGI:96437 HomoloGene: 499 GeneCards: 3485
فهم الوجود الجيني
الوظيفة الجزيئية	• insulin-like growth factor binding; • growth factor binding; • insulin-like growth factor I binding; • insulin-like growth factor II binding; • ‏GO:0001948 ربط بروتيني; • receptor binding;
المكونات الخلوية	• منطقة خارج الخلية; • apical plasma membrane; • extracellular exosome; • حويصلة سيتوبلازمية; • خارج خلوي;
العمليات الحيوية	• عملية التمثيل الغذائي للبروتين الخلوي; • response to estradiol; • response to retinoic acid; • response to nutrient; • حمل أنثوي; • response to steroid hormone; • response to mechanical stimulus; • شيخوخة; • response to glucocorticoid; • response to lithium ion; • response to estrogen; • regulation of insulin-like growth factor receptor signaling pathway; • cellular response to hormone stimulus; • regulation of cell growth; • regulation of growth; • negative regulation of canonical Wnt signaling pathway; • response to drug; • توصيل الإشارة; • positive regulation of activated T cell proliferation;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P18065
	P47877
	‏NM_001313992، ‏NM_001313993، ‏NM_000597 NM_001313990، ‏NM_001313992، ‏NM_001313993، ‏NM_000597
	‏NM_001310659، ‏XM_030250357 NM_008342، ‏NM_001310659، ‏XM_030250357
	‏NP_001300919، ‏NP_001300921، ‏NP_001300922 NP_000588، ‏NP_001300919، ‏NP_001300921، ‏NP_001300922
	‏NP_032368، ‏XP_030106217 NP_001297588، ‏NP_032368، ‏XP_030106217
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

IGFBP2‏ (Insulin like growth factor binding protein 2) هوَ بروتين يُشَفر بواسطة جين IGFBP2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem. 265 (25): 14892–8. PMID 1697583.

قراءة متعمقة

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Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo". Pediatr. Nephrol. 14 (7): 572–8. doi:10.1007/s004670000362. PMID 10912521.
Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis". Cytokine Growth Factor Rev. 18 (3–4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236.
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Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)". Exp. Eye Res. 52 (5): 549–61. doi:10.1016/0014-4835(91)90056-K. PMID 1712312.
Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. Endocrinol. Metab. 73 (3): 658–66. doi:10.1210/jcem-73-3-658. PMID 1714916.
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Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species". Growth Regul. 1 (3): 125–30. PMID 1726837.
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Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)". EMBO J. 8 (9): 2497–502. PMC 401241. PMID 2479552.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544.
Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905.
Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. doi:10.1210/jc.81.7.2680. PMID 8675597.
Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography". Biochim. Biophys. Acta. 1313 (1): 79–88. doi:10.1016/0167-4889(96)00053-5. PMID 8781553.
Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia". Clin. Endocrinol. 46 (3): 333–42. doi:10.1046/j.1365-2265.1997.1100922.x. PMID 9156044.
Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.