ALAS1

ALAS1
المعهدات
الأسماء المستعارة	ALAS1, ALAS, ALAS3, ALASH, MIG4, ALAS-H, 5'-aminolevulinate synthase 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 125290 MGI: MGI:87989 HomoloGene: 55478 GeneCards: 211
فهم الوجود الجيني
الوظيفة الجزيئية	• نشاط انتنطقي; • pyridoxal phosphate binding; • transferase activity, transferring acyl groups; • ‏GO:0001948 ربط بروتيني; • نشاط تحفيزي; • 5-aminolevulinate synthase activity; • identical protein binding;
المكونات الخلوية	• مصفوفة ميتوكندرية; • ميتوكندريون; • بلازم نووي; • عصارة خلوية;
العمليات الحيوية	• heme biosynthetic process; • mitochondrion organization; • تمثيل غذائي; • protoporphyrinogen IX biosynthetic process; • biosynthetic process; • tetrapyrrole biosynthetic process; • porphyrin-containing compound metabolic process; • regulation of lipid metabolic process;
	المصادر:Amigo / QuickGO
أورثولوج
	P13196
	Q8VC19
	‏NM_000688، ‏NM_001304443، ‏NM_001304444، ‏NM_199166، ‏XM_011533477، ‏XM_017005873، ‏XM_024453393 XM_011533478، ‏NM_000688، ‏NM_001304443، ‏NM_001304444، ‏NM_199166، ‏XM_011533477، ‏XM_017005873، ‏XM_024453393
	‏NM_020559 NM_001291835، ‏NM_020559
	‏NP_001291372، ‏NP_001291373، ‏NP_954635، ‏XP_011531779، ‏XP_011531780، ‏XP_016861362، ‏XP_024309161 NP_000679، ‏NP_001291372، ‏NP_001291373، ‏NP_954635، ‏XP_011531779، ‏XP_011531780، ‏XP_016861362، ‏XP_024309161
	‏NP_065584 NP_001278764، ‏NP_065584
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ALAS1‏ (5'-aminolevulinate synthase 1) هوَ بروتين يُشَفر بواسطة جين ALAS1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Bishop DF, Henderson AS, Astrin KH (June 1990). "Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome". Genomics. 7 (2): 207–14. doi:10.1016/0888-7543(90)90542-3. PMID 2347585.
^ "Entrez Gene: Delta-aminolevulinate synthase 1". مؤرشف من الأصل في 07 مارس 2010.

قراءة متعمقة

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May BK, Bhasker CR, Bawden MJ, Cox TC (1990). "Molecular regulation of 5-aminolevulinate synthase. Diseases related to heme biosynthesis". Mol. Biol. Med. 7 (5): 405–21. PMID 2095458.
Dwyer BE, Smith MA, Richardson SL, et al. (2009). "Down-Regulation of Aminolevulinate Synthase, the Rate-Limiting Enzyme for Heme Biosynthesis in Alzheimer's Disease". Neurosci. Lett. 460 (2): 180–4. doi:10.1016/j.neulet.2009.05.058. PMC 2743886. PMID 19477221.
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Ferreira GC, Cheltsov AV (2002). "Circular permutation of 5-aminolevulinate synthase as a tool to evaluate folding, structure and function". Cell. Mol. Biol. (Noisy-le-grand). 48 (1): 11–6. PMID 11929042.
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