HIP2

UBE2K
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1YLA, 2O25, 3E46, 3F92, 3K9O, 3K9P, 5DFL
المعهدات
الأسماء المستعارة	UBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602846 MGI: MGI:1858216 HomoloGene: 3903 GeneCards: 3093
فهم الوجود الجيني
الوظيفة الجزيئية	• ubiquitin-protein transferase activity; • نشاط انتنطقي; • nucleotide binding; • ubiquitin-ubiquitin ligase activity; • ‏GO:0001948 ربط بروتيني; • ATP binding; • ubiquitin protein ligase binding; • ubiquitin conjugating enzyme activity;
المكونات الخلوية	• سيتوبلازم; • filopodium tip; • نواة; • عصارة خلوية;
العمليات الحيوية	• protein K48-linked ubiquitination; • positive regulation of type I interferon-mediated signaling pathway; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • free ubiquitin chain polymerization; • positive regulation of peptidyl-threonine phosphorylation; • ubiquitin-dependent protein catabolic process; • cellular response to interferon-beta; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of proteasomal ubiquitin-dependent protein catabolic process; • protein ubiquitination;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P61086
	P61087
	‏NM_001111112، ‏NM_001111113، ‏NM_001312646، ‏NM_001312647، ‏NM_001312648 NM_005339، ‏NM_001111112، ‏NM_001111113، ‏NM_001312646، ‏NM_001312647، ‏NM_001312648
	‏NM_001310618، ‏NM_001310619، ‏NR_144566 NM_016786، ‏NM_001310618، ‏NM_001310619، ‏NR_144566
	‏NP_001104583، ‏NP_001299575، ‏NP_001299576، ‏NP_001299577، ‏NP_005330 NP_001104582، ‏NP_001104583، ‏NP_001299575، ‏NP_001299576، ‏NP_001299577، ‏NP_005330
	‏NP_001297548، ‏NP_058066 NP_001297547، ‏NP_001297548، ‏NP_058066
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

HIP2‏ (Ubiquitin conjugating enzyme E2 K) هوَ بروتين يُشَفر بواسطة جين HIP2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885.
↑ "Entrez Gene: HIP2 huntingtin interacting protein 2". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625.

قراءة متعمقة

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