NKX6-1

NKX6-1
المعهدات
الأسماء المستعارة	NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602563 MGI: MGI:1206039 HomoloGene: 4495 GeneCards: 4825
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • sequence-specific DNA binding; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • chromatin binding; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • ربط دي إذا إي; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
المكونات الخلوية	• نواة; • extracellular exosome;
العمليات الحيوية	• smoothened signaling pathway; • detection of glucose; • pancreas development; • نسخ الدنا; • regulation of axon extension; • نمومتعدد الخلايا; • cellular response to peptide hormone stimulus; • central nervous system neuron differentiation; • response to nicotine; • negative regulation of glial cell differentiation; • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; • type B pancreatic cell proliferation; • cellular response to cytokine stimulus; • positive regulation of sequence-specific DNA binding transcription factor activity; • neurogenesis; • ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني; • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; • type B pancreatic cell development; • positive regulation of neuron differentiation; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of type B pancreatic cell development; • type B pancreatic cell maturation; • oligodendrocyte differentiation; • ضبط نسخ الدنا; • cellular proliferation; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • transcription from RNA polymerase II promoter; • response to drug; • positive regulation of glial cell differentiation; • تمايز خلوي; • positive regulation of insulin secretion; • تشكل العضوالحيواني; • regulation of neuron migration; • neuron migration; • regulation of insulin secretion; • endocrine pancreas development; • type B pancreatic cell differentiation;
	المصادر:Amigo / QuickGO
أورثولوج
	P78426
	Q99MA9
	NM_006168
	NM_144955
	NP_006159
	NP_659204
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

NKX6-1‏ (NK6 homeobox 1) هوَ بروتين يُشَفر بواسطة جين NKX6-1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: NK6 homeobox 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.

قراءة متعمقة

Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1". Mol. Cell. Biol. 28 (10): 3465–76. doi:10.1128/MCB.01791-07. PMC 2423154. PMID 18347054.
Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1". FEBS Lett. 461 (3): 287–94. doi:10.1016/S0014-5793(99)01436-2. PMID 10567713.
Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1". Mol. Endocrinol. 18 (6): 1363–75. doi:10.1210/me.2004-0006. PMID 15056733.
Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes. 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704.
Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci. 54 (5): 996–1002. doi:10.1007/s10620-008-0459-8. PMID 18754095.