CD2AP

CD2AP
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2FEI, 2J6F, 2J6K, 2J6O, 2J7I, 3AA6, 3LK4, 3U23, 4WCI, 4X1V
المعهدات
الأسماء المستعارة	CD2AP, CMS, CD2-associated protein, CD2 associated protein
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604241 MGI: MGI:1330281 HomoloGene: 7663 GeneCards: 23607
فهم الوجود الجيني
الوظيفة الجزيئية	• beta-catenin binding; • SH3 domain binding; • ‏GO:0032403 macromolecular complex binding; • structural constituent of cytoskeleton; • protein C-terminus binding; • ‏GO:0001948 ربط بروتيني; • vascular endothelial growth factor receptor binding; • cadherin binding;
المكونات الخلوية	• filamentous actin; • إسقاط خلية; • intercellular junction; • ruffle; • endocytic vesicle; • cell leading edge; • actin cytoskeleton; • perinuclear region of cytoplasm; • extracellular exosome; • هيكل خلوي; • سيتوبلازم; • غشاء خلوي; • موصل خلوي; • macromolecular complex;
العمليات الحيوية	• regulation of actin cytoskeleton reorganization; • negative regulation of transforming growth factor beta1 production; • vesicle organization; • substrate-dependent cell migration, cell extension; • انقسام خلوي; • دورة الخلية; • cell migration; • regulation of receptor-mediated endocytosis; • توصيل الإشارة; • proteasome-mediated ubiquitin-dependent protein catabolic process; • positive regulation of protein localization to nucleus; • actin filament organization; • negative regulation of small GTPase mediated signal transduction; • cell-cell adhesion; • macromolecular complex assembly; • positive regulation of protein secretion;
	المصادر:Amigo / QuickGO
أورثولوج
	Q9Y5K6
	Q9JLQ0
	‏NM_012120، ‏XM_005248976، ‏XM_017010641 XM_011514449، ‏NM_012120، ‏XM_005248976، ‏XM_017010641
	‏XM_011246263، ‏XM_011246264، ‏XM_011246265، ‏XR_001782031 NM_009847، ‏XM_011246263، ‏XM_011246264، ‏XM_011246265، ‏XR_001782031
	‏XP_005249033، ‏XP_011512751، ‏XP_016866130 NP_036252، ‏XP_005249033، ‏XP_011512751، ‏XP_016866130
	‏XP_011244565، ‏XP_011244566، ‏XP_011244567 NP_033977، ‏XP_011244565، ‏XP_011244566، ‏XP_011244567
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

CD2AP‏ (CD2 associated protein) هوَ بروتين يُشَفر بواسطة جين CD2AP في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H (Jun 1999). "CMS: An adapter molecule involved in cytoskeletal rearrangements". Proc Natl Acad Sci USA. 96 (11): 6211–6. doi:10.1073/pnas.96.11.6211. PMC 26861. PMID 10339567.
^ "Entrez Gene: CD2AP CD2-associated protein". مؤرشف من الأصل فيثمانية مارس 2010.

قراءة متعمقة

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS (1998). "A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts". Cell. 94 (5): 667–77. doi:10.1016/S0092-8674(00)81608-6. PMID 9741631. مؤرشف من الأصل في 20 ديسمبر 2017.
Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E (2000). "In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2". J. Biol. Chem. 275 (42): 32888–93. doi:10.1074/jbc.M006624200. PMID 10913159.
Li C, Ruotsalainen V, Tryggvason K, Shaw AS, Miner JH (2000). "CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere". Am. J. Physiol. Renal Physiol. 279 (4): F785–92. PMID 10997929.
Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H (2001). "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology ثلاثة domain interaction". J. Biol. Chem. 276 (7): 4957–63. doi:10.1074/jbc.M005784200. PMID 11067845.
Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P (2002). "Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin". J. Clin. Invest. 108 (11): 1621–9. doi:10.1172/JCI12849. PMC 200981. PMID 11733557.
Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA (2003). "The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse". Immunity. 18 (1): 141–54. doi:10.1016/S1074-7613(02)00516-2. PMID 12530983.
Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic. 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.
Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ (2003). "A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton". J. Biol. Chem. 278 (24): 21805–13. doi:10.1074/jbc.M211407200. PMID 12672817.
Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH (2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85". J. Biol. Chem. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.
Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS (2003). "CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility". Science. 300 (5623): 1298–300. doi:10.1126/science.1081068. PMID 12764198.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (2004). "Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin". Am. J. Pathol. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA (2005). "Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes". J. Am. Soc. Nephrol. 16 (3): 629–37. doi:10.1681/ASN.2004030172. PMID 15659563.