TMED2

TMED2
المعهدات
الأسماء المستعارة	TMED2, P24A, RNP24, p24, p24b1, p24beta1, transmembrane p24 trafficking protein 2
معهدات خارجية	MGI: MGI:3704329 HomoloGene: 55991 GeneCards: 10959
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني;
المكونات الخلوية	• transport vesicle; • مكون تكاملي للغشاء; • ER to Golgi transport vesicle membrane; • جهاز غولجي; • Golgi membrane; • intracellular membrane-bounded organelle; • Golgi cisterna membrane; • zymogen granule membrane; • غشاء; • شبكة إندوبلازمية; • endoplasmic reticulum membrane; • cytoplasmic vesicle membrane; • حويصلة سيتوبلازمية; • COPI-coated vesicle; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • COPI-coated vesicle membrane; • COPII-coated ER to Golgi transport vesicle;
العمليات الحيوية	• cargo loading into vesicle; • neural tube closure; • maternal placenta development; • embryonic placenta development; • COPII vesicle coating; • ER to Golgi vesicle-mediated transport; • heart looping; • positive regulation of gene expression; • تكون الجسيدات; • Golgi organization; • post-anal tail morphogenesis; • embryonic morphogenesis; • multicellular organism growth; • in utero embryonic development; • protein transport; • negative regulation of GTPase activity; • COPI coating of Golgi vesicle; • labyrinthine layer blood vessel development; • vesicle-mediated transport; • somite rostral/caudal axis specification; • intracellular protein transport; • retrograde vesicle-mediated transport, Golgi to ER; • protein localization to plasma membrane;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q15363
	Q9R0Q3
	‏NM_001321445 NM_006815، ‏NM_001321445
	XM_003945446
	‏NP_006806 NP_001308374، ‏NP_006806
	NP_062744
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

TMED2‏ (Transmembrane p24 trafficking protein 2) هوَ بروتين يُشَفر بواسطة جين TMED2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (September 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
^ "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Fiedler K, Veit M, Stamnes MA, Rothman JE (1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors". Science. 273 (5280): 1396–9. Bibcode:1996Sci...273.1396F. doi:10.1126/science.273.5280.1396. PMID 8703076.
Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Lett. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941.
Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell. 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
Barr FA, Preisinger C, Kopajtich R, Körner R (2002). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chen F, Hasegawa H, Schmitt-Ulms G, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur.440.1208C. doi:10.1038/nature04667. PMID 16641999.
Luo W, Wang Y, Reiser G (2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking". J. Biol. Chem. 282 (41): 30246–55. doi:10.1074/jbc.M703205200. PMID 17693410.