NOL1

NOP2
المعهدات
الأسماء المستعارة	NOP2, NOL1, NOP120, NSUN1, p120, nucleolar protein
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 164031 MGI: MGI:107891 HomoloGene: 135865 GeneCards: 4839
فهم الوجود الجيني
الوظيفة الجزيئية	• methyltransferase activity; • نشاط انتنطقي; • ‏GO:0001948 ربط بروتيني; • S-adenosylmethionine-dependent methyltransferase activity; • rRNA (cytosine-C5-)-methyltransferase activity; • RNA binding;
المكونات الخلوية	• نواة; • نوية; • بلازم نووي;
العمليات الحيوية	• rRNA processing; • مثيلة; • rRNA base methylation; • maturation of LSU-rRNA; • ضبط زيادي للتكاثر الخلوي; • ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني; • ribosomal large subunit assembly; • regulation of signal transduction by p53 class mediator; • ribosome biogenesis;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P46087
	Q922K7
	‏NM_001258308، ‏NM_001258309، ‏NM_001258310، ‏NM_006170، ‏XM_005253691 NM_001033714، ‏NM_001258308، ‏NM_001258309، ‏NM_001258310، ‏NM_006170، ‏XM_005253691
	‏XM_030255097 NM_138747، ‏XM_030255097
	‏NP_001245237، ‏NP_001245238، ‏NP_001245239، ‏NP_006161، ‏XP_005253748 NP_001028886، ‏NP_001245237، ‏NP_001245238، ‏NP_001245239، ‏NP_006161، ‏XP_005253748
	n/a
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

NOL1‏ (NOP2 nucleolar protein) هوَ بروتين يُشَفر بواسطة جين NOL1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: NOL1 nucleolar protein 1, 120kDa". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402.
^ Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591. مؤرشف من الأصل فيعشرة أكتوبر 2008.
^ Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415. مؤرشف من الأصل في 05 سبتمبر 2008.
^ Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.

قراءة متعمقة

Busch H (1990). "The final common pathway of cancer". Cancer Res. 50 (16): 4830–8. PMID 2199030.
Valdez BC, Perlaky L, Saijo Y, Henning D, Zhu C, Busch RK, Zhang WW, Busch H (1992). "A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation". Cancer Res. 52 (20): 5681–6. PMID 1394192.
Larson RG, Henning D, Haidar MA, Jhiang S, Lin WL, Zhang WW, Busch H (1990). "Genomic structure of the human proliferating cell nucleolar protein P120". Cancer Commun. 2 (2): 63–71. PMID 2372471.
Fonagy A, Henning D, Jhiang S, Haidar M, Busch RK, Larson R, Valdez B, Busch H (1989). "Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120". Cancer Commun. 1 (4): 243–51. PMID 2576976.
Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.
Valdez BC, Perlaky L, Henning D, Saijo Y, Chan PK, Busch H (1994). "Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23". J. Biol. Chem. 269 (38): 23776–83. PMID 8089149.
Jallal B, Mossie K, Vasiloudis G, Knyazev P, Zachwieja J, Clairvoyant F, Schilling J, Ullrich A (1997). "The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase". J. Biol. Chem. 272 (18): 12158–63. doi:10.1074/jbc.272.18.12158. PMID 9115287.
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