• glucose homeostasis • regulation of exocytosis • positive regulation of protein secretion • intracellular protein transport • negative regulation of G-protein coupled receptor protein signaling pathway • response to drug • إخراج خلوي • regulation of calcium ion-dependent exocytosis • positive regulation of insulin secretion
RPH3AL (Rabphilin 3A like (without C2 domains)) هوَ بروتين يُشَفر بواسطة جين RPH3AL في الإنسان.
الوظيفة
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
الأهمية السريرية
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
المراجع
^Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (July 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.
^"Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)". مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S (November 1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells". The Journal of Biological Chemistry. 272 (47): 29407–10. doi:10.1074/jbc.272.47.29407. PMID 9367993.
Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (January 2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron. 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
Haynes LP, Evans GJ, Morgan A, Burgoyne RD (March 2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells". The Journal of Biological Chemistry. 276 (13): 9726–32. doi:10.1074/jbc.M006959200. PMID 11134008.
Goi T, Takeuchi K, Katayama K, Hirose K, Yamaguchi A (2003). "Mutations of rabphillin-3A-like gene in colorectal cancers". Oncology Reports. 9 (6): 1189–92. doi:10.3892/or.9.6.1189. PMID 12375017.
Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H (February 2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits". The Journal of Biological Chemistry. 278 (6): 4072–81. doi:10.1074/jbc.M208898200. PMID 12446671.
Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (April 2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (January 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Molecular Endocrinology. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T (March 2004). "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells". Biochemical and Biophysical Research Communications. 316 (1): 218–25. doi:10.1016/j.bbrc.2004.02.026. PMID 15003533.
Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (June 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U (January 2008). "Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma". Frontiers in Bioscience. 13 (1): 1050–61. doi:10.2741/2742. PMC 2667692. PMID 17981610.
تاريخ النشر:
2020-06-02 13:14:40
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