GRLF1

ARHGAP35
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2K85, 3C5H, 3FK2
المعهدات
الأسماء المستعارة	ARHGAP35, GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP, Rho GTPase activating protein 35
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605277 MGI: MGI:1929494 HomoloGene: 35136 GeneCards: 2909
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إذا إي; • RNA polymerase II regulatory region sequence-specific DNA binding; • ‏GO:0001106 transcription corepressor activity; • GTP binding; • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • phospholipid binding; • GTPase activator activity; • GTPase activity; • nucleotide binding; • lipid binding;
المكونات الخلوية	• سيتوبلازم; • عصارة خلوية; • actin cytoskeleton; • نواة; • هيكل خلوي; • إسقاط خلية; • غشاء خلوي; • غشاء; • ciliary basal body;
العمليات الحيوية	• ضبط نسخ الدنا; • negative regulation of Rho protein signal transduction; • negative regulation of transcription from RNA polymerase II promoter; • نسخ الدنا; • neural tube closure; • regulation of cell shape; • forebrain development; • camera-type eye development; • negative regulation of transcription, DNA-templated; • regulation of small GTPase mediated signal transduction; • توصيل الإشارة; • negative regulation of vascular permeability; • positive regulation of GTPase activity; • axon guidance; • axonal fasciculation; • regulation of actin polymerization or depolymerization; • positive regulation of neuron projection development; • cell migration; • central nervous system neuron axonogenesis; • تطور الثدي; • establishment or maintenance of actin cytoskeleton polarity; • cellular response to extracellular stimulus; • regulation of actin cytoskeleton organization; • wound healing, spreading of cells; • positive regulation of cilium assembly; • regulation of axonogenesis; • neuron projection guidance;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9NRY4
	Q91YM2
	‏NM_024342، ‏XM_024451473، ‏XR_002958305 NM_004491، ‏NM_024342، ‏XM_024451473، ‏XR_002958305
	‏XM_006539809، ‏XM_011250512 NM_172739، ‏XM_006539809، ‏XM_011250512
	‏XP_024307241 NP_004482، ‏XP_024307241
	‏XP_006539872، ‏XP_011248814 NP_766327، ‏XP_006539872، ‏XP_011248814
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

GRLF1‏ (Rho GTPase activating protein 35) هوَ بروتين يُشَفر بواسطة جين GRLF1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ LeClerc S, Palaniswami R, Xie BX, Govindan MV (Sep 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". The Journal of Biological Chemistry. 266 (26): 17333–40. PMID 1894621.

قراءة متعمقة

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Warriar N, Pagé N, Govindan MV (Aug 1996). "Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element". The Journal of Biological Chemistry. 271 (31): 18662–71. doi:10.1074/jbc.271.31.18662. PMID 8702520.
Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H (Oct 2000). "p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas". Gene. 257 (1): 23–31. doi:10.1016/S0378-1119(00)00387-5. PMID 11054565.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L (Oct 2005). "p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling". Journal of Cell Science. 118 (Pt 20): 4689–700. doi:10.1242/jcs.02590. PMID 16188938.
Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D (Jan 2006). "Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability". The Journal of Biological Chemistry. 281 (4): 2296–305. doi:10.1074/jbc.M511248200. PMID 16308318.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo". The Journal of Biological Chemistry. 282 (33): 23910–8. doi:10.1074/jbc.M702169200. PMID 17562701.