فهم الجينوم البنيوي
فهم الجينوم البنيوي Structural genomics، هوفهم يبحث في وصف البنية ثلاثية الأبعاد لأي بروتين عن طريق الجينوم.
الأهداف
الأساليب
de novo methods
Modelling-based methods
ab initio modeling
Sequence-based modeling
Threading
أمثلة على فهم الجينوم البنيوي
The Thermotogo maritima proteome
The Mycobacterium tuberculosis proteome
قواعد بيانات وتصنيفات بنية البروتين
انظر أيضا
- فهم الجينوم
- Omics
- Structural proteomics
- Protein Structure Initiative
المصادر
-
Hooft RW, Vriend G, Sander C, Abola EE (1996). "Errors in protein structures". Nature. 381 (6580): 272. doi:10.1038/381272a0. PMID 8692262. Unknown parameter
|month=ignored (help)CS1 maint: multiple names: authors list (link) - Marsden RL, Lewis TA, Orengo CA (2007). "Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint". BMC Bioinformatics. 8: 86. doi:10.1186/1471-2105-8-86. PMC 1829165. PMID 17349043.CS1 maint: multiple names: authors list (link)
- Baker EN, Arcus AL, Lott JS. 2003. Protein structure prediction and analysis as a tool for functional genomics. ‘’Applied Bioinformatics’’ 2(3 Suppl):S3-S10.
- Goulding CW ‘’et al’’. 2003. Structural genoimcs of ‘’Mycobacterium tuberculosis’’: a preliminary report of progress at UCLA. ‘’Biophysical Chemistry’’ 105: 361-370.
- Lesley SA ‘’et al’’. 2002. Structural genomics of the ‘’Thermotoga maritima’’ proteome implemented in a high-throughput structure determination pipeline. ‘’PNAS’’ 99(18):11664-11669.
- Skolnick J, Fetrow JS, and Kolinski A. 2000. Structural genomics and its importance for gene function analysis. ‘’Nature Biotechnology’’ 18:283-287.
وصلات خارجية
- Structural Genomics Consortium
- Protein Structure Initiative (PSI)
- PSI Structural Genomics Knowledgebase: A Nature Gateway
- Northeast Structural Genomics Consortium
- The Midwest Center for Structural Genomics
- Berkeley Structural Genomics Center
- Center for Eukaryotic Structural Genomics
- Yeast Structural Genomics (Genomique Structurale de la levure)
- RIKEN Structural Genomics/Proteomics Initiative
- Structural Genomics of Pathogenic Protozoa
- The Joint Center for Structural Genomics
- Mycobacterium tuberculosis Structural Genomics Consortium
- New York SGX Research Center for Structural Genomics (NYSGXRC)
- NJCST Initiative in Structural Genomics and Bioinformatics
- Structural Genomics at Brookhaven Natl. Labs
- Structure to Function Pilot Project: CARB
- The Southeast Collaboratory for Structural Genomics
- Toronto Structural Proteomics Consortium
- Protein Structure Factory
- Oxford Protein Production Facility
- Seattle Structural Genomics Center for Infectious Disease
- Structural Proteomics in Europe SPINE
- Forum for European Structural Proteomics (FESP)
- Israel Structural Proteomics Center (ISPC)
