جسم مضاد وحيد النسيلة
تمثيل عام ل"الأساليب المُستخدمة" في إنتاج الأجسام المُضادة.
الأجسام المضادة وحيدة النسيلة هي أجسام مُضادة أحادية النوعية هي نفسها تتكون من قبل خلايا المناعة التي هي كلها مُتطابقة من حيث الاستنساخ من الخلية الأم.
الاستكشاف
هذا القسم فارغ أوغير مكتمل، مساعدتكم مرحب بها!
الاستخدامات
علاج السرطان
Monoclonal antibodies for cancer. ADEPT, antibody directed enzyme prodrug therapy; ADCC, antibody dependent cell-mediated cytotoxicity; CDC, complement dependent cytotoxicity; MAb, monoclonal antibody; scFv, single-chain Fv fragment.
الأمثلة
Below are examples of clinically important monoclonal antibodies.
| التصنيف الرئيسي | النوع | الاستخدام | الآلية/الهدف | Mode |
|---|---|---|---|---|
| Anti- inflammatory |
infliximab |
|
inhibits TNF-α | chimeric |
| adalimumab |
|
inhibits TNF-α | human | |
| basiliximab |
|
inhibits IL-2 on activated T cells | chimeric | |
| daclizumab |
|
inhibits IL-2 on activated T cells | humanized | |
| omalizumab |
|
inhibits human immunoglobulin E (IgE) | humanized | |
| Anti-cancer | gemtuzumab |
|
targets myeloid cell surface antigen CD33 on leukemia cells | humanized |
| alemtuzumab |
|
targets an antigen CD52 on T- and B-lymphocytes | humanized | |
| rituximab |
|
targets phosphoprotein CD20 on B lymphocytes | chimeric | |
| trastuzumab |
|
targets the HER2/neu (erbB2) receptor | humanized | |
| nimotuzumab |
|
EGFR inhibitor | Humanized | |
| cetuximab |
|
EGFR inhibitor | Chimeric | |
| bevacizumab |
|
inhibits VEGF | humanized | |
| Other | palivizumab |
|
inhibits an RSV fusion (F) protein | humanized |
| abciximab |
|
inhibits the receptor GpIIb/IIIa on platelets | chimeric |
اقرأ أيضًا
- قائمة الأجسام المضادة وحيدة النسيلة
- ترازتوموماب
- Antibody mimetic
- Immunotoxins, which sometimes use monoclonal antibodies as the targeting mechanism
- List of monoclonal antibodies
- Monoclonal antibody therapy
- Nomenclature of monoclonal antibodies
- Polyclonal antibodies
- Queen Mab Small mythological figure symbolizing hope (popular culture, used as biotech pun).
الهامش
-
^ Modified from Carter P (2001). "Improving the efficacy of antibody-based cancer therapies". Nat. Rev. Cancer. 1 (2): 118–29. doi:10.1038/35101072. PMID 11905803. Unknown parameter
|month=ignored (help) - ^ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. pp. 241, for the examples infliximab, basiliximab, abciximab, daclizumab, palivusamab, gemtuzumab, alemtuzumab and rituximab, and mechanism and mode. ISBN .
وصلات خارجية
- Monoclonal Antibodies Animation (Flash Required)
- Monoclonal Antibodies, from John W. Kimball's online biology textbook
- MeSH Monoclonal+antibodies
- Antibodypedia, open-access virtual repository publishing data and commentary on any antibodies available to the scientific community.
نطقب:Engineered antibodies
