ROCK2

ROCK2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	4L6Q, 4WOT
المعهدات
الأسماء المستعارة	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604002 MGI: MGI:107926 HomoloGene: 21010 GeneCards: 9475
فهم الوجود الجيني
الوظيفة الجزيئية	• نشاط انتنطقي; • nucleotide binding; • protein kinase activity; • structural molecule activity; • ربط أيون فلزي; • kinase activity; • protein serine/threonine kinase activity; • ‏GO:0001948 ربط بروتيني; • Rho GTPase binding; • ATP binding; • Rho-dependent protein serine/threonine kinase activity; • RNA binding; • tau protein binding; • tau-protein kinase activity; • GTP-Rho binding;
المكونات الخلوية	• سيتوبلازم; • جسيم مركزي; • غشاء; • غشاء خلوي; • microtubule organizing center; • حبيبة رنا; • هيكل خلوي; • نواة; • عصارة خلوية; • داخل خلوي;
العمليات الحيوية	• smooth muscle contraction; • positive regulation of protein phosphorylation; • intracellular signal transduction; • regulation of actin cytoskeleton organization; • centrosome duplication; • فسفرة; • rhythmic process; • ephrin receptor signaling pathway; • cellular response to testosterone stimulus; • انقسام السيتوبلازم; • positive regulation of centrosome duplication; • regulation of stress fiber assembly; • regulation of cell motility; • positive regulation of endothelial cell migration; • protein phosphorylation; • negative regulation of bicellular tight junction assembly; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of gene expression; • regulation of cell adhesion; • regulation of circadian rhythm; • Rho protein signal transduction; • regulation of focal adhesion assembly; • negative regulation of angiogenesis; • regulation of keratinocyte differentiation; • negative regulation of myosin-light-chain-phosphatase activity; • I-kappaB kinase/NF-kappaB signaling; • regulation of establishment of cell polarity; • cortical actin cytoskeleton organization; • regulation of establishment of endothelial barrier; • actin cytoskeleton organization; • protein localization to plasma membrane; • G-protein coupled receptor signaling pathway; • aortic valve morphogenesis; • positive regulation of cardiac muscle hypertrophy; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • positive regulation of cell migration; • positive regulation of connective tissue growth factor production; • positive regulation of MAPK cascade; • regulation of protein metabolic process; • positive regulation of stress fiber assembly; • negative regulation of biomineral tissue development; • response to transforming growth factor beta; • positive regulation of fibroblast growth factor production; • regulation of angiotensin-activated signaling pathway; • negative regulation of protein localization to lysosome; • positive regulation of amyloid-beta formation; • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; • positive regulation of protein localization to early endosome; • positive regulation of amyloid precursor protein catabolic process; • positive regulation of connective tissue replacement; • response to angiotensin; • response to ischemia; • negative regulation of gene expression; • regulation of neurological system process; • negative regulation of nitric oxide biosynthetic process; • mRNA destabilization; • regulation of blood vessel diameter; • regulation of cellular response to hypoxia; • cellular response to acetylcholine; • mitotic cytokinesis; • actomyosin structure organization; • embryonic morphogenesis; • regulation of cell junction assembly;
	المصادر:Amigo / QuickGO
أورثولوج
	O75116; C9JFJ0
	P70336
	‏NM_004850، ‏XM_005246190، ‏NM_001321643، ‏XM_017005378، ‏XM_017005379 XM_011510417، ‏NM_004850، ‏XM_005246190، ‏NM_001321643، ‏XM_017005378، ‏XM_017005379
	‏XM_006515019، ‏XM_006515020 NM_009072، ‏XM_006515019، ‏XM_006515020
	‏NP_004841، ‏XP_005246247، ‏XP_011508719، ‏XP_016860867، ‏XP_016860868 NP_001308572، ‏NP_004841، ‏XP_005246247، ‏XP_011508719، ‏XP_016860867، ‏XP_016860868
	‏XP_006515082، ‏XP_006515083 NP_033098، ‏XP_006515082، ‏XP_006515083
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ROCK2‏ (Rho associated coiled-coil containing protein kinase 2) هوَ بروتين يُشَفر بواسطة جين ROCK2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". مؤرشف من الأصل في 19 أغسطس 2017. اطلع عليه بتاريخ 21 أبريل 2016.

قراءة متعمقة

Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.