VPS24

CHMP3
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2XZE, 3FRT, 3FRV, 2GD5
المعهدات
الأسماء المستعارة	CHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 610052 MGI: MGI:1913950 HomoloGene: 6368 GeneCards: 51652
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني; • phosphatidylcholine binding; • protein homodimerization activity; • ubiquitin-specific protease binding; • identical protein binding;
المكونات الخلوية	• سيتوبلازم; • غشاء; • غشاء خلوي; • جسيم داخلي; • late endosome membrane; • extracellular exosome; • ESCRT III complex; • عصارة خلوية; • داخل خلوي; • late endosome; • حويصلة سيتوبلازمية; • multivesicular body;
العمليات الحيوية	• autophagosome maturation; • دورة حياة الفيروس; • protein polymerization; • multivesicular body assembly; • دورة الخلية; • انقسام خلوي; • regulation of mitotic spindle assembly; • endosomal transport; • regulation of centrosome duplication; • استماتة; • protein heterooligomerization; • vacuolar transport; • cell separation after cytokinesis; • protein transport; • nucleus organization; • mitotic metaphase plate congression; • multivesicular body sorting pathway; • regulation of exosomal secretion; • macroautophagy; • multivesicular body-lysosome fusion; • regulation of early endosome to late endosome transport; • نقل; • viral budding via host ESCRT complex; • endosome transport via multivesicular body sorting pathway; • late endosome to vacuole transport; • midbody abscission;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9Y3E7
	Q9CQ10
	‏NM_001005753، ‏NM_001193517، ‏NM_016079 NR_036454، ‏NM_001005753، ‏NM_001193517، ‏NM_016079
	‏XM_006506481، ‏NM_001355674، ‏NM_001355675، ‏NM_001361405، ‏XM_030255546 NM_025783، ‏XM_006506481، ‏NM_001355674، ‏NM_001355675، ‏NM_001361405، ‏XM_030255546
	‏NP_001180446، ‏NP_057163 NP_001005753، ‏NP_001180446، ‏NP_057163
	‏XP_006506544، ‏NP_001342603، ‏NP_001342604، ‏NP_001348334، ‏XP_030111406 NP_080059، ‏XP_006506544، ‏NP_001342603، ‏NP_001342604، ‏NP_001348334، ‏XP_030111406
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

VPS24‏ (Charged multivesicular body protein 3) هوَ بروتين يُشَفر بواسطة جين VPS24 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab. 86 (9): 4504–11. doi:10.1210/jc.86.9.4504. PMID 11549700.
^ Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem. 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588.
^ "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD (2002). "Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting". Dev. Cell. 3 (2): 271–82. doi:10.1016/S1534-5807(02)00220-4. PMID 12194857.
Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, Fisher PB (2003). "Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization". J. Neurovirol. 9 (3): 372–89. doi:10.1080/13550280390201263. PMID 12775420.
Strack B, Calistri A, Craig S, Popova E, Göttlinger HG (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI (2005). "Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1". J. Biol. Chem. 280 (13): 12799–809. doi:10.1074/jbc.M413968200. PMID 15632132.
Yan Q, Hunt PR, Frelin L, Vida TA, Pevsner J, Bean AJ (2005). "mVps24p functions in EGF receptor sorting/trafficking from the early endosome". Exp. Cell Res. 304 (1): 265–73. doi:10.1016/j.yexcr.2004.11.003. PMID 15707591.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Walker GE, Antoniono RJ, Ross HJ, Paisley TE, Oh Y (2006). "Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1". Oncogene. 25 (13): 1943–54. doi:10.1038/sj.onc.1209213. PMID 16302002.
Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, Wälchli S, Lukacs GL, Brech A, Stenmark H (2006). "The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor". Mol. Biol. Cell. 17 (6): 2513–23. doi:10.1091/mbc.E05-10-0915. PMC 1474783. PMID 16554368.
Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Zamborlini A, Usami Y, Radoshitzky SR, Popova E, Palu G, Göttlinger H (2007). "Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 19140–5. doi:10.1073/pnas.0603788103. PMC 1748189. PMID 17146056.