TUSC2

TUSC2
المعهدات
الأسماء المستعارة	TUSC2, C3orf11, FUS1, PAP, PDAP2, tumor suppressor candidate 2, tumor suppressor 2, mitochondrial calcium regulator
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607052 MGI: MGI:1931086 HomoloGene: 5264 GeneCards: 11334
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني;
المكونات الخلوية	• ميتوكندريون;
العمليات الحيوية	• regulation of mitochondrial membrane potential; • cell-cell signaling; • دورة الخلية; • chemokine (C-C motif) ligandخمسة production; • cellular proliferation; • inflammatory response; • negative regulation of interleukin-17 production; • cell maturation; • neutrophil mediated killing of gram-negative bacterium; • regulation of reactive oxygen species metabolic process; • defense response to Gram-negative bacterium; • interleukin-15 production; • positive regulation of interleukin-10 production; • بلعمة; • natural killer cell differentiation;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O75896
	Q9WVF8
	NM_007275
	NM_019742
	NP_009206
	NP_062716
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

TUSC2‏ (Tumor suppressor 2, mitochondrial calcium regulator) هوَ بروتين يُشَفر بواسطة جين TUSC2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Fischer WH, Schubert D (Jan 1997). "Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem. 66 (5): 2213–6. doi:10.1046/j.1471-4159.1996.66052213.x. PMID 8780057.
^ Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzmin I, Lerman M, Roth J, Minna JD (Oct 2001). "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells". Oncogene. 20 (43): 6258–62. doi:10.1038/sj.onc.1204832. PMID 11593436.
^ "Entrez Gene: TUSC2 tumor suppressor candidate 2". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Prudkin L, Behrens C, Liu DD, et al. (2008). "Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer". Clin. Cancer Res. 14 (1): 41–7. doi:10.1158/1078-0432.CCR-07-1252. PMC 2833352. PMID 18172250.
Lee DY, Deng Z, Wang CH, Yang BB (2008). "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20350–5. doi:10.1073/pnas.0706901104. PMC 2154434. PMID 18077375.
Lin J, Sun T, Ji L, et al. (2007). "Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1". Oncogene. 26 (49): 6989–96. doi:10.1038/sj.onc.1210500. PMC 3457636. PMID 17486070.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Uno F, Sasaki J, Nishizaki M, et al. (2004). "Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells". Cancer Res. 64 (9): 2969–76. doi:10.1158/0008-5472.CAN-03-3702. PMID 15126327.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.