FBXW7

FBXW7
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2OVP, 2OVQ, 2OVR, 5IBK
المعهدات
الأسماء المستعارة	FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606278 MGI: MGI:1354695 HomoloGene: 117451 GeneCards: 55294
فهم الوجود الجيني
الوظيفة الجزيئية	• protein binding, bridging; • ‏GO:0001948 ربط بروتيني; • ubiquitin-protein transferase activator activity; • identical protein binding; • ubiquitin protein ligase binding; • cyclin binding; • phosphothreonine residue binding; • ubiquitin-protein transferase activity; • ubiquitin binding;
المكونات الخلوية	• سيتوبلازم; • Parkin-FBXW7-Cul1 ubiquitin ligase complex; • SCF ubiquitin ligase complex; • بلازم نووي; • نوية; • نواة; • عصارة خلوية; • ميتوكندريون; • شبكة إندوبلازمية; • جهاز غولجي; • perinuclear region of cytoplasm;
العمليات الحيوية	• positive regulation of epidermal growth factor-activated receptor activity; • positive regulation of protein targeting to mitochondrion; • negative regulation of SREBP signaling pathway; • cellular response to UV; • negative regulation of triglyceride biosynthetic process; • protein stabilization; • negative regulation of hepatocyte proliferation; • sister chromatid cohesion; • cellular response to DNA damage stimulus; • regulation of protein localization; • positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • vasculature development; • regulation of autophagy of mitochondrion; • negative regulation of DNA endoreduplication; • positive regulation of ubiquitin-protein transferase activity; • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; • protein ubiquitination; • lipid homeostasis; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell cycle G1/S phase transition; • regulation of lipid storage; • viral process; • positive regulation of proteasomal protein catabolic process; • positive regulation of protein ubiquitination; • negative regulation of Notch signaling pathway; • protein polyubiquitination; • تعديل ما بعد الترجمة; • negative regulation of osteoclast development; • vasculogenesis; • Notch signaling pathway; • negative regulation of gene expression; • ubiquitin recycling; • lung development; • protein destabilization; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of cell migration involved in sprouting angiogenesis; • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; • regulation of circadian rhythm; • rhythmic process;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q969H0
	Q8VBV4
	‏NM_001013415، ‏NM_001257069، ‏NM_018315، ‏NM_033632، ‏XM_011532084، ‏XM_011532085، ‏XM_011532086، ‏XM_011532087، ‏NM_001349798، ‏XM_024454121، ‏XM_024454122، ‏XM_024454123، ‏XM_024454124، ‏XM_024454125، ‏XM_024454126 XM_011532088، ‏NM_001013415، ‏NM_001257069، ‏NM_018315، ‏NM_033632، ‏XM_011532084، ‏XM_011532085، ‏XM_011532086، ‏XM_011532087، ‏NM_001349798، ‏XM_024454121، ‏XM_024454122، ‏XM_024454123، ‏XM_024454124، ‏XM_024454125، ‏XM_024454126
	‏NM_001177774، ‏NM_080428، ‏XM_006501656، ‏XM_006501657، ‏XM_006501658، ‏XM_030252669 NM_001177773، ‏NM_001177774، ‏NM_080428، ‏XM_006501656، ‏XM_006501657، ‏XM_006501658، ‏XM_030252669
	‏NP_001243998، ‏NP_060785، ‏NP_361014، ‏XP_011530386، ‏XP_011530387، ‏XP_011530388، ‏XP_011530389، ‏XP_011530390، ‏NP_001336727، ‏XP_024309889، ‏XP_024309890، ‏XP_024309891، ‏XP_024309892، ‏XP_024309893، ‏XP_024309894 NP_001013433، ‏NP_001243998، ‏NP_060785، ‏NP_361014، ‏XP_011530386، ‏XP_011530387، ‏XP_011530388، ‏XP_011530389، ‏XP_011530390، ‏NP_001336727، ‏XP_024309889، ‏XP_024309890، ‏XP_024309891، ‏XP_024309892، ‏XP_024309893، ‏XP_024309894
	‏NP_001171245، ‏NP_536353، ‏XP_006501719، ‏XP_006501720، ‏XP_006501721، ‏XP_030108529 NP_001171244، ‏NP_001171245، ‏NP_536353، ‏XP_006501719، ‏XP_006501720، ‏XP_006501721، ‏XP_030108529
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FBXW7‏ (F-box and WD repeat domain containing 7) هوَ بروتين يُشَفر بواسطة جين FBXW7 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israël A (Sep 2001). "Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor". J Biol Chem. 276 (37): 34371–8. doi:10.1074/jbc.M101343200. PMID 11425854.
^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
^ "Entrez Gene: FBXW7 F-box and WD repeat domain containing 7". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

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