• microtubule polymerization • positive regulation of protein complex assembly • positive regulation of protein polymerization • microtubule bundle formation
TPPP (Tubulin polymerization promoting protein) هوَ بروتين يُشَفر بواسطة جين TPPP في الإنسان.
الوظيفة
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
الأهمية السريرية
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
المراجع
^Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283.
^"Entrez Gene: TPPP brain-specific protein p25 alpha". مؤرشف من الأصل في 05 ديسمبر 2010.
^Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica (باللغة الإنجليزية). 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN 0001-6322. PMID 17123092. مؤرشف من الأصل في 14 يونيو2018.
^Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200.
^Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652.
^Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. مؤرشف من الأصل في 07 ديسمبر 2019.
^Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737.
^Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174.
قراءة متعمقة
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tirián L, Hlavanda E, Oláh J, et al. (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13976–81. doi:10.1073/pnas.2436331100. PMC 283531. PMID 14623963.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lehotzky A, Tirián L, Tökési N, et al. (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival". J. Cell Sci. 117 (Pt 25): 6249–59. doi:10.1242/jcs.01550. PMID 15564385.
DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Jämsä A, Bäckström A, Gustafsson E, et al. (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells". Biochem. Biophys. Res. Commun. 345 (1): 324–31. doi:10.1016/j.bbrc.2006.04.032. PMID 16678793.
Skjoerringe T, Lundvig DM, Jensen PH, Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain". J. Neurochem. 99 (1): 333–42. doi:10.1111/j.1471-4159.2006.04073.x. PMID 16879710.
Oláh J, Tokési N, Vincze O, et al. (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies". FEBS Lett. 580 (25): 5807–14. doi:10.1016/j.febslet.2006.09.037. PMID 17027006.
Hlavanda E, Klement E, Kókai E, et al. (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases". J. Biol. Chem. 282 (40): 29531–9. doi:10.1074/jbc.M703466200. PMID 17693641.
Song YJ, Lundvig DM, Huang Y, et al. (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy". Am. J. Pathol. 171 (4): 1291–303. doi:10.2353/ajpath.2007.070201. PMC 1988878. PMID 17823288.
تاريخ النشر:
2020-06-02 12:57:27
التصنيفات:
جينات على كروموسوم 5, صفحات بها مراجع بالإنجليزية (en), صفحات تستعمل قالبا ببيانات مكررة, مقالات بها أقسام فارغة منذ يوليو 2018, جميع المقالات التي بها أقسام فارغة, صفحات بها بيانات ويكي بيانات, صفحات تستخدم خاصية P639, معرفات مركب كيميائي, بوابة طب/مقالات متعلقة, بوابة الكيمياء الحيوية/مقالات متعلقة, بوابة علم الأحياء الخلوي والجزيئي/مقالات متعلقة, جميع المقالات التي تستخدم شريط بوابات, جميع مقالات البذور, بذرة جين على كروموسوم 5
