HAPLN1

HAPLN1
المعهدات
الأسماء المستعارة	HAPLN1, CRTL1, CRT1, hyaluronan and proteoglycan link protein 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 115435 MGI: MGI:1337006 HomoloGene: 1420 GeneCards: 1404
فهم الوجود الجيني
الوظيفة الجزيئية	• extracellular matrix structural constituent; • hyaluronic acid binding; • extracellular matrix structural constituent conferring compression resistance;
المكونات الخلوية	• نسيج خارج الخلية; • منطقة خارج الخلية; • نسيج خارج الخلية البروتيني; • تشابك عصبي; • collagen-containing extracellular matrix;
العمليات الحيوية	• skeletal system development; • extracellular matrix organization; • central nervous system development; • التصاق الخلايا;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P10915
	Q9QUP5
	‏XM_011543168، ‏XM_017009051، ‏XM_017009052، ‏XM_017009053، ‏XM_017009054 NM_001884، ‏XM_011543168، ‏XM_017009051، ‏XM_017009052، ‏XM_017009053، ‏XM_017009054
	‏XM_006517075 NM_013500، ‏XM_006517075
	‏XP_011541470، ‏XP_016864540، ‏XP_016864541، ‏XP_016864542، ‏XP_016864543 NP_001875، ‏XP_011541470، ‏XP_016864540، ‏XP_016864541، ‏XP_016864542، ‏XP_016864543
	‏XP_006517138 NP_038528، ‏XP_006517138
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

HAPLN1‏ (Hyaluronan and proteoglycan link protein 1) هوَ بروتين يُشَفر بواسطة جين HAPLN1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: HAPLN1 hyaluronan and proteoglycan link protein 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Dudhia J, Hardingham TE (May 1990). "The primary structure of human cartilage link protein". Nucleic Acids Res. 18 (5): 1292. doi:10.1093/nar/18.5.1292. PMC 330454. PMID 2320422.
^ Osborne-Lawrence SL, Sinclair AK, Hicks RC, Lacey SW, Eddy RL Jr, Byers MG, Shows TB, Duby AD (Mar 1991). "Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene". Genomics. 8 (3): 562–7. doi:10.1016/0888-7543(90)90044-U. PMID 2286376.

قراءة متعمقة

Mundlos S, Meyer R, Yamada Y, Zabel B (1992). "Distribution of cartilage proteoglycan (aggrecan) core protein and link protein gene expression during human skeletal development". Matrix. 11 (5): 339–46. doi:10.1016/s0934-8832(11)80205-2. PMID 1725805.
Rhodes C, Savagner P, Line S, et al. (1991). "Characterization of the promoter for the rat and human link protein gene". Nucleic Acids Res. 19 (8): 1933–9. doi:10.1093/nar/19.8.1933. PMC 328126. PMID 2030970.
Dudhia J, Hardingham TE (1990). "The primary structure of human cartilage link protein". Nucleic Acids Res. 18 (8): 2214. doi:10.1093/nar/18.8.2214. PMC 330736. PMID 2336413.
Perkins SJ, Nealis AS, Dudhia J, Hardingham TE (1989). "Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein". J. Mol. Biol. 206 (4): 737–53. doi:10.1016/0022-2836(89)90580-9. PMID 2738916.
Nguyen Q, Murphy G, Hughes CE, et al. (1993). "Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein". Biochem. J. ( Pt 2): 595–8. PMC 1134922. PMID 7694569.
Dudhia J, Bayliss MT, Hardingham TE (1994). "Human link protein gene: structure and transcription pattern in chondrocytes". Biochem. J. ( Pt 1): 329–33. PMC 1137594. PMID 7945259.
Guerassimov A, Zhang Y, Banerjee S, et al. (1998). "Autoimmunity to cartilage link protein in patients with rheumatoid arthritis and ankylosing spondylitis". J. Rheumatol. 25 (8): 1480–4. PMID 9712087.
Perveen R, Hart-Holden N, Dixon MJ, et al. (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3". Genomics. 57 (2): 219–26. doi:10.1006/geno.1999.5766. PMID 10198161.
Hirakawa S, Oohashi T, Su WD, et al. (2000). "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain". Biochem. Biophys. Res. Commun. 276 (3): 982–9. doi:10.1006/bbrc.2000.3583. PMID 11027579.
Pokharna HK, Pottenger LA (2000). "Glycation induced crosslinking of link proteins, in vivo and in vitro". J. Surg. Res. 94 (1): 35–42. doi:10.1006/jsre.2000.6000. PMID 11038300.
Milz S, Schlüter T, Putz R, et al. (2001). "Fibrocartilage in the transverse ligament of the human atlas". Spine. 26 (16): 1765–71. doi:10.1097/00007632-200108150-00007. PMID 11493848.
Sun GW, Kobayashi H, Suzuki M, et al. (2003). "Production of cartilage link protein by human granulosa-lutein cells". J. Endocrinol. 175 (2): 505–15. doi:10.1677/joe.0.1750505. PMID 12429048.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Spicer AP, Joo A, Bowling RA (2003). "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links". J. Biol. Chem. 278 (23): 21083–91. doi:10.1074/jbc.M213100200. PMID 12663660.
Matsumoto K, Shionyu M, Go M, et al. (2003). "Distinct interaction of versican/PG-M with hyaluronan and link protein". J. Biol. Chem. 278 (42): 41205–12. doi:10.1074/jbc.M305060200. PMID 12888576.
Shi S, Grothe S, Zhang Y, et al. (2004). "Link protein has greater affinity for versican than aggrecan". J. Biol. Chem. 279 (13): 12060–6. doi:10.1074/jbc.M310091200. PMID 14724283.
Kou I, Ikegawa S (2005). "SOX9-dependent and -independent transcriptional regulation of human cartilage link protein". J. Biol. Chem. 279 (49): 50942–8. doi:10.1074/jbc.M406786200. PMID 15456769.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.