SFRS5

SRSF5
المعهدات
الأسماء المستعارة	SRSF5, HRS, SFRS5, SRP40, serine/arginine-rich splicing factor 5, serine and arginine rich splicing factor 5
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600914 HomoloGene: 134432 GeneCards: 6430
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني; • ربط حمض نووي; • protein kinase B binding; • RNA binding;
المكونات الخلوية	• بلازم نووي; • نوية; • نواة; • عصارة خلوية; • nuclear speck;
العمليات الحيوية	• mRNA splicing, via spliceosome; • termination of RNA polymerase II transcription; • mRNA processing; • mRNA export from nucleus; • regulation of cell cycle; • تجدد الكبد; • mRNA splice site selection; • cellular response to insulin stimulus; • mRNA 3'-end processing; • liver development; • تضفير الآر حتى إيه; • response to insulin; • RNA export from nucleus; • positive regulation of RNA splicing; • regulation of alternative mRNA splicing, via spliceosome; • mRNA cis splicing, via spliceosome;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q13243; G3V5K8
	n/a
	‏NM_001039465، ‏NM_006925، ‏XM_005267999، ‏XM_005268000، ‏XM_011537077، ‏XR_943505، ‏NM_001320214، ‏XM_017021593، ‏XM_017021594، ‏XR_001750508، ‏XR_001750509، ‏XR_001750510، ‏XR_001750512، ‏XR_001750513، ‏XR_001750514 XR_943506، ‏NM_001039465، ‏NM_006925، ‏XM_005267999، ‏XM_005268000، ‏XM_011537077، ‏XR_943505، ‏NM_001320214، ‏XM_017021593، ‏XM_017021594، ‏XR_001750508، ‏XR_001750509، ‏XR_001750510، ‏XR_001750512، ‏XR_001750513، ‏XR_001750514
	n/a
	‏NP_001307143، ‏NP_008856، ‏XP_005268056، ‏XP_005268057، ‏XP_011535379، ‏XP_016877082، ‏XP_016877083 NP_001034554، ‏NP_001307143، ‏NP_008856، ‏XP_005268056، ‏XP_005268057، ‏XP_011535379، ‏XP_016877082، ‏XP_016877083
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

SFRS5‏ (Serine/arginine-rich-splicing factor 5) هوَ بروتين يُشَفر بواسطة جين SFRS5 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Diamond RH, Du K, Lee VM, Mohn KL, Haber BA, Tewari DS, Taub R (July 1993). "Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing". The Journal of Biological Chemistry. 268 (20): 15185–92. PMID 7686911.
^ "Entrez Gene: SFRS5 splicing factor, arginine/serine-rich 5". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

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Gui JF, Lane WS, Fu XD (June 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
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Du K, Taub R (December 1997). "Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes". Gene. 204 (1–2): 243–9. doi:10.1016/S0378-1119(97)00552-0. PMID 9434190.
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Papoutsopoulou S, Nikolakaki E, Chalepakis G, Kruft V, Chevaillier P, Giannakouros T (July 1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Research. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
Guil S, Gattoni R, Carrascal M, Abián J, Stévenin J, Bach-Elias M (April 2003). "Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation". Molecular and Cellular Biology. 23 (8): 2927–41. doi:10.1128/MCB.23.8.2927-2941.2003. PMC 152554. PMID 12665590.
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Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
de Graaf K, Hekerman P, Spelten O, Herrmann A, Packman LC, Büssow K, Müller-Newen G, Becker W (February 2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". The Journal of Biological Chemistry. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
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Ropers D, Ayadi L, Gattoni R, Jacquenet S, Damier L, Branlant C, Stévenin J (July 2004). "Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA". The Journal of Biological Chemistry. 279 (29): 29963–73. doi:10.1074/jbc.M404452200. PMID 15123677.
Caputi M, Freund M, Kammler S, Asang C, Schaal H (June 2004). "A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression". Journal of Virology. 78 (12): 6517–26. doi:10.1128/JVI.78.12.6517-6526.2004. PMC 416506. PMID 15163745.
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