CYTH2

CYTH2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1PBV, 1R8M, 1R8Q, 1R8S, 1S9D, 4JMI, 4JMO, 4JWL, 4JXH, 4L5M, 4Z21
المعهدات
الأسماء المستعارة	CYTH2, ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin 2, cytohesin-2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602488 MGI: MGI:1334255 HomoloGene: 32116 GeneCards: 9266
فهم الوجود الجيني
الوظيفة الجزيئية	• inositol 1,4,5 trisphosphate binding; • ‏GO:0001948 ربط بروتيني; • guanyl-nucleotide exchange factor activity; • lipid binding; • ARF guanyl-nucleotide exchange factor activity;
المكونات الخلوية	• سيتوبلازم; • growth cone; • غشاء خلوي; • إسقاط خلية; • غشاء; • Golgi membrane; • عصارة خلوية; • adherens junction; • bicellular tight junction; • موصل خلوي;
العمليات الحيوية	• regulation of ARF protein signal transduction; • إدخال خلوي; • actin cytoskeleton organization;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q99418; F8W8E2
	P63034
	‏NM_004228، ‏NM_017457، ‏XM_006723472، ‏XR_001753791، ‏XR_001753792 XM_006723473، ‏NM_004228، ‏NM_017457، ‏XM_006723472، ‏XR_001753791، ‏XR_001753792
	‏NM_011181، ‏XR_003946419 NM_001112701، ‏NM_011181، ‏XR_003946419
	‏NP_059431، ‏XP_006723535، ‏XP_006723536 NP_004219، ‏NP_059431، ‏XP_006723535، ‏XP_006723536
	‏NP_035311 NP_001106171، ‏NP_035311
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

CYTH2‏ (Cytohesin 2) هوَ بروتين يُشَفر بواسطة جين CYTH2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Chardin P, Paris S, Antonny B, Robineau S, Béraud-Dufour S, Jackson CL, Chabre M (1996). "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608): 481–4. doi:10.1038/384481a0. PMID 8945478.
^ Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (Sep 1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. doi:10.1016/S0092-8674(00)80095-1. PMID 8706128.

قراءة متعمقة

Meacci E, Tsai SC, Adamik R, Moss J, Vaughan M (1997). "Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1745–8. doi:10.1073/pnas.94.5.1745. PMC 19987. PMID 9050849.
Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. doi:10.1074/jbc.273.1.23. PMID 9417041.
Mossessova E, Gulbis JM, Goldberg J (1998). "Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase". Cell. 92 (3): 415–23. doi:10.1016/S0092-8674(00)80933-2. PMID 9476900.
Cherfils J, Ménétrey J, Mathieu M, Le Bras G, Robineau S, Béraud-Dufour S, Antonny B, Chardin P (1998). "Structure of the Sec7 domain of the Arf exchange factor ARNO". Nature. 392 (6671): 101–5. doi:10.1038/32210. PMID 9510256.
Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ (1998). "Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase". Curr. Biol. 8 (8): 463–6. doi:10.1016/S0960-9822(98)70181-2. PMID 9550703.
Kim HS (1998). "Assignment of the human cts18.1 gene PSCD2L to chromosome 19 band q13 using a radiation hybrid mapping panel". Cytogenet. Cell Genet. 83 (1–2): 43. doi:10.1159/000015163. PMID 9925920.
Santy LC, Frank SR, Hatfield JC, Casanova JE (1999). "Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch". Curr. Biol. 9 (20): 1173–6. doi:10.1016/S0960-9822(00)80019-6. PMID 10531036.
Ogasawara M, Kim SC, Adamik R, Togawa A, Ferrans VJ, Takeda K, Kirby M, Moss J, Vaughan M (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221–30. doi:10.1074/jbc.275.5.3221. PMID 10652308.
Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". J. Biol. Chem. 275 (28): 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148.
Macia E, Paris S, Chabre M (2000). "Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids". Biochemistry. 39 (19): 5893–901. doi:10.1021/bi992795w. PMID 10801341.
Lee SY, Pohajdak B (2000). "N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi". J. Cell Sci. 113 (11): 1883–9. PMID 10806099.
Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ (2001). "beta-Arrestin-mediated ADP-ribosylation factorستة activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45): 42509–13. doi:10.1074/jbc.M108399200. PMID 11533043.
Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. PMID 11850456.
Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.
Buchet-Poyau K, Mehenni H, Radhakrishna U, Antonarakis SE (2002). "Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2". Cytogenet. Genome Res. 97 (3–4): 171–8. doi:10.1159/000066620. PMID 12438709.
Huh M, Han JH, Lim CS, Lee SH, Kim S, Kim E, Kaang BK (2003). "Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons". J. Neurochem. 85 (1): 282–5. doi:10.1046/j.1471-4159.2003.01718.x. PMID 12641750.