AKAP8L

AKAP8L
المعهدات
الأسماء المستعارة	AKAP8L, HA95, HAP95, NAKAP, NAKAP95, A-kinase anchoring proteinثمانية like
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 609475 MGI: MGI:1860606 HomoloGene: 8658 GeneCards: 26993
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط أيون فلزي; • lamin binding; • histone deacetylase binding; • DEAD/H-box RNA helicase binding; • ربط دي إذا إي; • ‏GO:0001948 ربط بروتيني; • RNA binding; • protein kinase A regulatory subunit binding;
المكونات الخلوية	• مصفوفة نووية; • كروماتين; • nuclear speck; • PML body; • نواة; • سيتوبلازم; • ribonucleoprotein;
العمليات الحيوية	• positive regulation of histone deacetylation; • nuclear envelope disassembly; • regulation of mRNA export from nucleus; • mitotic chromosome condensation; • cell cycle G2/M phase transition; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • regulation of histone phosphorylation; • نسخ الدنا; • ضبط نسخ الدنا; • تضفير الآر حتى إيه; • mRNA processing;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9ULX6; M0QYT7
	Q9R0L7
	‏NM_014371، ‏NR_111971 NM_001291478، ‏NM_014371، ‏NR_111971
	‏XM_011246534 NM_017476، ‏XM_011246534
	‏NP_055186 NP_001278407، ‏NP_055186
	n/a
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

AKAP8L‏ (A-kinase anchoring proteinثمانية like) هوَ بروتين يُشَفر بواسطة جين AKAP8L في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (Jan 2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95". Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 92 (1): 27–37. doi:10.1016/S0248-4900(00)88761-4. PMID 10761695.
^ "Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F (Jul 2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element". The Journal of Biological Chemistry. 275 (28): 21396–21401. doi:10.1074/jbc.M909887199. PMID 10748171.

قراءة متعمقة

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Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis". Neuromolecular Medicine. 7 (4): 297–310. doi:10.1385/NMM:7:4:297. PMID 16391387.