USF2

USF2
المعهدات
الأسماء المستعارة	USF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600390 MGI: MGI:99961 HomoloGene: 2527 GeneCards: 7392
فهم الوجود الجيني
الوظيفة الجزيئية	• sequence-specific DNA binding; • ربط دي إذا إي; • protein dimerization activity; • protein homodimerization activity; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • bHLH transcription factor binding; • ‏GO:0001948 ربط بروتيني; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
المكونات الخلوية	• intracellular membrane-bounded organelle; • نواة; • بلازم نووي;
العمليات الحيوية	• ضبط نسخ الدنا; • positive regulation of transcription from RNA polymerase II promoter by glucose; • ضبط النسخ انطلاقاً من محفز بوليميراز الرنا الثاني; • late viral transcription; • transcription from RNA polymerase II promoter; • نسخ الدنا; • positive regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter by glucose; • lipid homeostasis; • رضاعة; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q15853; M0QYU7
	Q64705
	‏NM_003367، ‏NM_207291، ‏XM_005259197، ‏XM_011527260، ‏NM_001321150، ‏XM_017027199، ‏XM_024451684، ‏XM_024451685 XM_011527261، ‏NM_003367، ‏NM_207291، ‏XM_005259197، ‏XM_011527260، ‏NM_001321150، ‏XM_017027199، ‏XM_024451684، ‏XM_024451685
	‏XM_006539733 NM_011680، ‏XM_006539733
	‏NP_003358، ‏NP_997174، ‏XP_005259254، ‏XP_011525562، ‏XP_011525563، ‏XP_016882688، ‏XP_024307452، ‏XP_024307453 NP_001308079، ‏NP_003358، ‏NP_997174، ‏XP_005259254، ‏XP_011525562، ‏XP_011525563، ‏XP_016882688، ‏XP_024307452، ‏XP_024307453
	‏XP_006539796 NP_035810، ‏XP_006539796
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

USF2‏ (Upstream transcription factor 2, c-fos interacting) هوَ بروتين يُشَفر بواسطة جين USF2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Dec 1996). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics. 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795.
^ "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Corre S, Galibert MD (Jan 2006). "[USF as a key regulatory element of gene expression]". Médecine Sciences. 22 (1): 62–7. doi:10.1051/medsci/200622162. PMID 16386222.
Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M (1993). "Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers". Gene Expression. 2 (3): 231–40. PMID 1450663.
Blanar MA, Rutter WJ (May 1992). "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos". Science. 256 (5059): 1014–8. doi:10.1126/science.1589769. PMID 1589769.
Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Ghosh AK, Datta PK, Jacob ST (Feb 1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.
Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.
Breen GA, Jordan EM (Apr 1997). "Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2". The Journal of Biological Chemistry. 272 (16): 10538–42. doi:10.1074/jbc.272.16.10538. PMID 9099698.
Nechushtan H, Zhang Z, Razin E (Apr 1997). "Microphthalmia (mi) in murine mast cells: regulation of its stimuli-mediated expression on the translational level". Blood. 89 (8): 2999–3008. PMID 9108421.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Breen GA, Jordan EM (Aug 1999). "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300". Biochimica et Biophysica Acta. 1428 (2–3): 169–76. doi:10.1016/s0304-4165(99)00061-6. PMID 10434034.
Kumari D, Usdin K (Feb 2001). "Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome". The Journal of Biological Chemistry. 276 (6): 4357–64. doi:10.1074/jbc.M009629200. PMID 11058604.
Kolonics A, Apáti A, Nahajevszky S, Gáti R, Brózik A, Magócsi M (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia". Haematologia. 31 (2): 125–38. doi:10.1163/15685590152492936. PMID 11583024.
Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (Jul 2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". The Biochemical Journal. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMC 1222691. PMID 11945176.
Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, Walterhouse DO, Iannaccone PM (Apr 2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis. 32 (4): 247–58. doi:10.1002/gene.10078. PMID 11948912.
Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
Pickwell GV, Shih H, Quattrochi LC (Apr 2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology. 65 (7): 1087–96. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044.
Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG (Oct 2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood. 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.