STCH

HSPA13
المعهدات
الأسماء المستعارة	HSPA13, STCH, heat shock protein family A (Hsp70) member 13
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 601100 MGI: MGI:1309463 HomoloGene: 5062 GeneCards: 6782
فهم الوجود الجيني
الوظيفة الجزيئية	• nucleotide binding; • ‏GO:0001948 ربط بروتيني; • ATP binding; • ATPase activity; • heat shock protein binding; • protein binding involved in protein folding; • unfolded protein binding; • misfolded protein binding;
المكونات الخلوية	• extracellular exosome; • شبكة إندوبلازمية; • intracellular membrane-bounded organelle; • نواة; • سيتوبلازم; • endoplasmic reticulum lumen; • غشاء; • endoplasmic reticulum chaperone complex;
العمليات الحيوية	• response to unfolded protein; • ubiquitin-dependent ERAD pathway; • endoplasmic reticulum unfolded protein response; • cellular response to heat; • cellular response to unfolded protein; • protein refolding; • chaperone mediated protein folding requiring cofactor;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P48723
	Q8BM72
	NM_006948
	‏NR_027492، ‏XM_006522849 NM_030201، ‏NR_027492، ‏XM_006522849
	NP_008879
	‏XP_006522912 NP_084477، ‏XP_006522912
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

STCH‏ (Heat shock protein family A (Hsp70) member 13) هوَ بروتين يُشَفر بواسطة جين STCH في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Brodsky G, Otterson GA, Parry BB, Hart I, Patterson D, Kaye FJ (Feb 1997). "Localization of STCH to human chromosome 21q11.1". Genomics. 30 (3): 627–8. doi:10.1006/geno.1995.1291. PMID 8825657.
^ "Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

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Otterson GA, Flynn GC, Kratzke RA, et al. (1994). "Stch encodes the 'ATPase core' of a microsomal stress 70 protein". EMBO J. 13 (5): 1216–25. PMC 394931. PMID 8131751.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kaye FJ, Modi S, Ivanovska I, et al. (2000). "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch". FEBS Lett. 467 (2–3): 348–55. doi:10.1016/S0014-5793(00)01135-2. PMID 10675567.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Aoki M, Yamamoto K, Ohyama S, et al. (2005). "A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population". Biochem. Biophys. Res. Commun. 335 (2): 566–74. doi:10.1016/j.bbrc.2005.07.110. PMID 16087163.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.