ميسيلات
في الكيمياء، تعتبر الميسيلات Mesylate أي ملح أوإستر لحمض الميثان سلفونيك (CH3SO3H). في الأملاح تتواجد الميسيلات في صورة أنيونCH3SO3− .
وعند تعديل الأسماء الدولية غير المملوكة INN لمادة دوائية تحوي هذه المجموعة أوالأيون فالتهجئة السليمة ستكون mesilate .
Mesylate esters are a group of organic compounds that share a common functional group with the general structure CH3SO2O-R , abbreviated MsO-R, where R is an organic substituent. Mesylate is considered an excellent leaving group in nucleophilic substitution reactions.
Mesyl is the term for the methylsulfonyl or CH3SO2- (Ms-) functional group. For example, methanesulfonyl chloride is often referred to as mesyl chloride.
التحضير
Mesylates may be prepared using an alcohol and methanesulfonyl chloride in the presence of a base, often amine bases such as triethylamine. Mesylates can also be prepared by combining an alcohol, methanesulfonic anhydride and base, although this method is generally used only if the nucleophilicity of chloride is a concern.
انظر أياض
- توسيلات
المصادر
- ^ World Health Organization (February 2006). "International Nonproprietary Names Modified". INN Working Document 05.167/3. WHO. Retrieved December 5, 2008.
- ^ نطقب:OrgSynth (a procedure illustrating the use of mesylates)
