LRRC8A

LRRC8A
المعهدات
الأسماء المستعارة	LRRC8A, AGM5, LRRC8, SWELL1, leucine-rich repeat containingثمانية family member A, leucine rich repeat containingثمانية family member A, leucine rich repeat containingثمانية VRAC subunit A
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 608360 MGI: MGI:2652847 HomoloGene: 18617 GeneCards: 56262
فهم الوجود الجيني
الوظيفة الجزيئية	• anion channel activity; • ‏GO:0001948 ربط بروتيني; • volume-sensitive anion channel activity; • identical protein binding;
المكونات الخلوية	• مكون تكاملي للغشاء; • cell surface; • ion channel complex; • غشاء; • سيتوبلازم; • غشاء خلوي; • integral component of plasma membrane;
العمليات الحيوية	• pre-B cell differentiation; • response to osmotic stress; • cell volume homeostasis; • تمايز خلوي; • ion transport; • anion transport; • regulation of anion transport; • anion transmembrane transport; • توصيل الإشارة; • نقل عبر الغشاء; • نقل; • inorganic anion transport; • taurine transport; • aspartate transport; • protein hexamerization;
	المصادر:Amigo / QuickGO
أورثولوج
	Q8IWT6
	Q80WG5
	‏NM_001127244، ‏NM_001127245، ‏NM_019594، ‏XM_005252095، ‏XM_005252096، ‏XM_006717186، ‏XM_011518863، ‏XM_011518864 XM_011518865، ‏NM_001127244، ‏NM_001127245، ‏NM_019594، ‏XM_005252095، ‏XM_005252096، ‏XM_006717186، ‏XM_011518863، ‏XM_011518864
	NM_177725
	‏NP_001120717، ‏NP_062540، ‏XP_005252152، ‏XP_005252153، ‏XP_006717249، ‏XP_011517165، ‏XP_011517166، ‏XP_011517167 NP_001120716، ‏NP_001120717، ‏NP_062540، ‏XP_005252152، ‏XP_005252153، ‏XP_006717249، ‏XP_011517165، ‏XP_011517166، ‏XP_011517167
	NP_808393
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

LRRC8A‏ (Leucine rich repeat containingثمانية VRAC subunit A) هوَ بروتين يُشَفر بواسطة جين LRRC8A في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Sawada A, Takihara Y, Kim JY, Matsuda-Hashii Y, Tokimasa S, Fujisaki H, Kubota K, Endo H, Onodera T, Ohta H, Ozono K, Hara J (December 2003). "A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans". The Journal of Clinical Investigation. 112 (11): 1707–13. doi:10.1172/JCI18937. PMC 281644. PMID 14660746.
^ Okada T, Islam MR, Tsiferova NA, Okada Y, Sabirov RZ (March 2017). "Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR)". Channels. 11 (2): 109–120. doi:10.1080/19336950.2016.1247133. PMC 5398601. PMID 27764579.
^ Yamada T, Wondergem R, Morrison R, Yin VP, Strange K (October 2016). "Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish". Physiological Reports. 4 (19): e12940. doi:10.14814/phy2.12940. PMC 5064130. PMID 27688432.
^ Jentsch TJ (May 2016). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature Reviews Molecular Cell Biology. 17 (5): 293–307. doi:10.1038/nrm.2016.29. PMID 27033257.
^ Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, Kucukosmanoglu A, Xu G, Voss FK, Reincke SM, Stauber T, Blomen VA, Vis DJ, Wessels LF, Brummelkamp TR, Borst P, Rottenberg S, Jentsch TJ (December 2015). "Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs". The EMBO Journal. 34 (24): 2993–3008. doi:10.15252/embj.201592409. PMC 4687416. PMID 26530471.
^ Lutter D, Ullrich F, Lueck JC, Kempa S, Jentsch TJ (March 2017). "Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels". Journal of Cell Science. 130 (6): 1122–1133. doi:10.1242/jcs.196253. PMID 28193731.
^ "Entrez Gene: LRRC8A leucine rich repeat containingثمانية family, member A". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T, Jentsch TJ (May 2014). "Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC". Science. 344 (6184): 634–8. doi:10.1126/science.1252826. PMID 24790029.
^ Hyzinski-García MC, Rudkouskaya A, Mongin AA (November 2014). "LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes". The Journal of Physiology. 592 (22): 4855–62. doi:10.1113/jphysiol.2014.278887. PMC 4259531. PMID 25172945.

قراءة متعمقة

Eggermont J, Trouet D, Carton I, Nilius B (2001). "Cellular function and control of volume-regulated anion channels". Cell Biochemistry and Biophysics. 35 (3): 263–74. doi:10.1385/CBB:35:3:263. PMID 11894846.
Mongin AA (March 2016). "Volume-regulated anion channel--a frenemy within the brain". Pflügers Archiv. 468 (3): 421–41. doi:10.1007/s00424-015-1765-6. PMC 4752865. PMID 26620797.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Kubota K, Kim JY, Sawada A, Tokimasa S, Fujisaki H, Matsuda-Hashii Y, Ozono K, Hara J (April 2004). "LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins". FEBS Letters. 564 (1–2): 147–52. doi:10.1016/S0014-5793(04)00332-1. PMID 15094057.
Smits G, Kajava AV (July 2004). "LRRC8 extracellular domain is composed of 17 leucine-rich repeats". Molecular Immunology. 41 (5): 561–2. doi:10.1016/j.molimm.2004.04.001. PMID 15183935.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.