MYOZ1

MYOZ1
المعهدات
الأسماء المستعارة	MYOZ1, CS-2, FATZ, MYOZ, myozenin 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605603 MGI: MGI:1929471 HomoloGene: 23311 GeneCards: 58529
فهم الوجود الجيني
الوظيفة الجزيئية	• FATZ binding; • ‏GO:0001948 ربط بروتيني; • actin binding; • telethonin binding; • protein serine/threonine phosphatase inhibitor activity;
المكونات الخلوية	• إسقاط خلية; • نواة; • قدم كاذب; • actin cytoskeleton; • Z disc;
العمليات الحيوية	• myofibril assembly; • negative regulation of transcription from RNA polymerase II promoter; • skeletal muscle tissue development; • negative regulation of phosphoprotein phosphatase activity; • negative regulation of skeletal muscle tissue regeneration; • skeletal muscle fiber adaptation; • sarcomere organization; • negative regulation of calcineurin-NFAT signaling cascade;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9NP98
	Q9JK37
	NM_021245
	NM_021508
	NP_067068
	NP_067483
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

MYOZ1‏ (Myozenin 1) هوَ بروتين يُشَفر بواسطة جين MYOZ1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: MYOZ1 myozenin 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Takada F, Vander Woude DL, Tong HQ, Thompson TG, Watkins SC, Kunkel LM, Beggs AH (Feb 2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines". Proc Natl Acad Sci USA. 98 (4): 1595–600. doi:10.1073/pnas.041609698. PMC 29302. PMID 11171996.
^ Faulkner G, Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojic' S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G (Jan 2001). "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle". J Biol Chem. 275 (52): 41234–42. doi:10.1074/jbc.M007493200. PMID 10984498.

قراءة متعمقة

Faulkner G, Pallavicini A, Formentin E, et al. (1999). "ZASP: a new Z-band alternatively spliced PDZ-motif protein". J. Cell Biol. 146 (2): 465–75. doi:10.1083/jcb.146.2.465. PMC 3206570. PMID 10427098.
Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gontier Y, Taivainen A, Fontao L, et al. (2006). "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins". J. Cell Sci. 118 (Pt 16): 3739–49. doi:10.1242/jcs.02484. PMID 16076904.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Arola AM, Sanchez X, Murphy RT, et al. (2007). "Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy". Mol. Genet. Metab. 90 (4): 435–40. doi:10.1016/j.ymgme.2006.12.008. PMID 17254821.
Posch MG, Perrot A, Dietz R, et al. (2007). "Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy". Mol. Genet. Metab. 91 (2): 207–8. doi:10.1016/j.ymgme.2007.02.014. PMID 17434779.