DUSP6

DUSP6
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1HZM, 1MKP
المعهدات
الأسماء المستعارة	DUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 6
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602748 MGI: MGI:1914853 HomoloGene: 55621 GeneCards: 1848
فهم الوجود الجيني
الوظيفة الجزيئية	• phosphoprotein phosphatase activity; • phosphatase activity; • نشاط هيدرولاز; • MAP kinase tyrosine/serine/threonine phosphatase activity; • protein tyrosine phosphatase activity; • protein tyrosine/serine/threonine phosphatase activity;
المكونات الخلوية	• بلازم نووي; • عصارة خلوية; • سيتوبلازم;
العمليات الحيوية	• negative regulation of protein phosphorylation; • تمايز خلوي; • positive regulation of cell death; • response to organic cyclic compound; • regulation of fibroblast growth factor receptor signaling pathway; • inactivation of MAPK activity; • protein dephosphorylation; • response to organic substance; • MAPK cascade; • activation of MAPK activity; • response to nitrosative stress; • positive regulation of apoptotic process; • negative regulation of ERK1 and ERK2 cascade; • peptidyl-tyrosine dephosphorylation; • response to growth factor; • dorsal/ventral pattern formation; • regulation of endodermal cell fate specification; • response to drug; • إزالة الفوسفات; • regulation of heart growth;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q16828
	Q9DBB1
	‏NM_001946 NM_022652، ‏NM_001946
	NM_026268
	‏NP_073143 NP_001937، ‏NP_073143
	NP_080544
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

DUSP6‏ (Dual specificity phosphatase 6) هوَ بروتين يُشَفر بواسطة جين DUSP6 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: DUSP6 dual specificity phosphatase 6". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S (February 1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". The Journal of Biological Chemistry. 271 (8): 4319–26. doi:10.1074/jbc.271.8.4319. PMID 8626780.
^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (June 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.

قراءة متعمقة

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM (July 1996). "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase". The EMBO Journal. 15 (14): 3621–32. PMC 451978. PMID 8670865.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A (1999). "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer". Cytogenetics and Cell Genetics. 82 (3–4): 156–9. doi:10.1159/000015091. PMID 9858808.
Stewart AE, Dowd S, Keyse SM, McDonald NQ (February 1999). "Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation". Nature Structural Biology. 6 (2): 174–81. doi:10.1038/5861. PMID 10048930.
Rössig L, Hermann C, Haendeler J, Assmus B, Zeiher AM, Dimmeler S (January 2002). "Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis". Basic Research in Cardiology. 97 (1): 1–8. doi:10.1007/s395-002-8381-2. PMID 11998972.
Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A (June 2003). "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer". The American Journal of Pathology. 162 (6): 1807–15. doi:10.1016/S0002-9440(10)64315-5. PMC 1868131. PMID 12759238.
Kim HS, Song MC, Kwak IH, Park TJ, Lim IK (September 2003). "Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence". The Journal of Biological Chemistry. 278 (39): 37497–510. doi:10.1074/jbc.M211739200. PMID 12840032.
Kim Y, Rice AE, Denu JM (December 2003). "Intramolecular dephosphorylation of ERK by MKP3". Biochemistry. 42 (51): 15197–207. doi:10.1021/bi035346b. PMID 14690430.
Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM (October 2004). "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal". The Journal of Biological Chemistry. 279 (40): 41882–91. doi:10.1074/jbc.M406720200. PMID 15269220.
Marchetti S, Gimond C, Chambard JC, Touboul T, Roux D, Pouysségur J, Pagès G (January 2005). "Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation". Molecular and Cellular Biology. 25 (2): 854–64. doi:10.1128/MCB.25.2.854-864.2005. PMC 543408. PMID 15632084.
Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M (March 2005). "Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases". Cell. 120 (5): 649–61. doi:10.1016/j.cell.2004.12.041. PMID 15766528.
Xu S, Furukawa T, Kanai N, Sunamura M, Horii A (2005). "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer". Journal of Human Genetics. 50 (4): 159–67. doi:10.1007/s10038-005-0235-y. PMID 15824892.
Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A (August 2005). "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas". Modern Pathology. 18 (8): 1034–42. doi:10.1038/modpathol.3800383. PMID 15832194.