GNG2 (G protein subunit gamma 2) هوَ بروتين يُشَفر بواسطة جين GNG2 في الإنسان.
الوظيفة
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
الأهمية السريرية
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
المراجع
^Modarressi MH, Taylor KE, Wolfe J (Jul 2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit". Biochem Biophys Res Commun. 272 (2): 610–5. doi:10.1006/bbrc.2000.2832. PMID 10833460.
^"Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2". مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
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Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
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Kostenis E, Conklin BR, Wess J (1997). "Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits". Biochemistry. 36 (6): 1487–95. doi:10.1021/bi962554d. PMID 9063897.
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Ong OC, Hu K, Rong H, et al. (1997). "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)". Genomics. 44 (1): 101–9. doi:10.1006/geno.1997.4814. PMID 9286705.
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Lett. 459 (2): 186–90. doi:10.1016/S0014-5793(99)01244-2. PMID 10518015.
Carman CV, Barak LS, Chen C, et al. (2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (14): 10443–52. doi:10.1074/jbc.275.14.10443. PMID 10744734.
Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq". J. Biol. Chem. 276 (26): 23945–53. doi:10.1074/jbc.M101154200. PMID 11294873.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Lowry WE, Huang XY (2002). "G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase". J. Biol. Chem. 277 (2): 1488–92. doi:10.1074/jbc.M110390200. PMID 11698416.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
Melliti K, Grabner M, Seabrook GR (2003). "The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells". J. Physiol. 546 (Pt 2): 337–47. doi:10.1113/jphysiol.2002.026716. PMC 2342512. PMID 12527722.
Wolfe JT, Wang H, Howard J, et al. (2003). "T-type calcium channel regulation by specific G-protein betagamma subunits". Nature. 424 (6945): 209–13. doi:10.1038/nature01772. PMID 12853961.
Niu J, Profirovic J, Pan H, et al. (2003). "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production". Circ. Res. 93 (9): 848–56. doi:10.1161/01.RES.0000097607.14733.0C. PMID 14512443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Doering CJ, Kisilevsky AE, Feng ZP, et al. (2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels". J. Biol. Chem. 279 (28): 29709–17. doi:10.1074/jbc.M308693200. PMID 15105422.
تاريخ النشر:
2020-06-02 13:09:46
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