TRAP1

TRAP1
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	4Z1F, 4Z1G, 4Z1H, 4Z1I, 5F3K, 5F5R
المعهدات
الأسماء المستعارة	TRAP1, HSP 75, HSP75, HSP90L, TRAP-1, TNF receptor associated protein 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606219 MGI: MGI:1915265 HomoloGene: 9457 GeneCards: 10131
فهم الوجود الجيني
الوظيفة الجزيئية	• nucleotide binding; • unfolded protein binding; • ‏GO:0001948 ربط بروتيني; • tumor necrosis factor receptor binding; • ATP binding; • protein kinase binding; • RNA binding;
المكونات الخلوية	• غشاء; • mitochondrial intermembrane space; • lipid droplet; • بلازم نووي; • مصفوفة ميتوكندرية; • ميتوكندريون; • mitochondrial inner membrane; • extracellular exosome;
العمليات الحيوية	• response to stress; • negative regulation of cellular respiration; • طي البروتين; • negative regulation of reactive oxygen species biosynthetic process; • translational attenuation; • chaperone-mediated protein folding; • negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q12931
	Q9CQN1
	‏NM_001272049، ‏NM_016292 XM_011522345، ‏NM_001272049، ‏NM_016292
	‏XR_001781856، ‏NR_152409 NM_026508، ‏XR_001781856، ‏NR_152409
	‏NP_057376، ‏XP_011520647 NP_001258978، ‏NP_057376، ‏XP_011520647
	NP_080784
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

TRAP1‏ (TNF receptor associated protein 1) هوَ بروتين يُشَفر بواسطة جين TRAP1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: TRAP1 TNF receptor-associated protein 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem. 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318.
^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093.

قراءة متعمقة

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Masuda Y, Shima G, Aiuchi T, et al. (2004). "Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin". J. Biol. Chem. 279 (41): 42503–15. doi:10.1074/jbc.M404256200. PMID 15292218.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736. PMID 16482509.
Im CN, Lee JS, Zheng Y, Seo JS (2007). "Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species". J. Cell. Biochem. 100 (2): 474–86. doi:10.1002/jcb.21064. PMID 16927372.