SOCS7

SOCS7
المعهدات
الأسماء المستعارة	SOCS7, NAP4, NCKAP4, suppressor of cytokine signaling 7
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 608788 MGI: MGI:2651588 HomoloGene: 16331 GeneCards: 30837
فهم الوجود الجيني
الوظيفة الجزيئية	• SH3 domain binding; • protein kinase inhibitor activity; • ‏GO:0001948 ربط بروتيني; • 1-phosphatidylinositol-3-kinase regulator activity;
المكونات الخلوية	• غشاء خلوي; • غشاء; • نواة; • سيتوبلازم; • عصارة خلوية; • phosphatidylinositol 3-kinase complex;
العمليات الحيوية	• insulin receptor signaling pathway; • regulation of growth; • negative regulation of signal transduction; • intracellular signal transduction; • cerebral cortex radially oriented cell migration; • layer formation in cerebral cortex; • fat cell differentiation; • protein ubiquitination; • negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • radial glia guided migration of Purkinje cell; • negative regulation of JAK-STAT cascade; • عملية حيوية; • regulation of phosphatidylinositol 3-kinase activity; • phosphatidylinositol phosphorylation;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O14512; A0A087WZ14
	Q8VHQ2
	‏XM_017024551، ‏XM_017024552، ‏XR_001752503 NM_014598، ‏XM_017024551، ‏XM_017024552، ‏XR_001752503
	‏XM_006532528، ‏XM_006532529، ‏XR_388369، ‏XR_001779922 NM_138657، ‏XM_006532528، ‏XM_006532529، ‏XR_388369، ‏XR_001779922
	‏XP_016880040، ‏XP_016880041 NP_055413، ‏XP_016880040، ‏XP_016880041
	‏XP_006532591، ‏XP_006532592 NP_619598، ‏XP_006532591، ‏XP_006532592
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

SOCS7‏ (Suppressor of cytokine signaling 7) هوَ بروتين يُشَفر بواسطة جين SOCS7 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: SOCS7 suppressor of cytokine signaling 7". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

قراءة متعمقة

Cooney RN (Feb 2002). "Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway". Shock. 17 (2): 83–90. doi:10.1097/00024382-200202000-00001. PMID 11837794.
Wormald S, Hilton DJ (Jan 2004). "Inhibitors of cytokine signal transduction". The Journal of Biological Chemistry. 279 (2): 821–4. doi:10.1074/jbc.R300030200. PMID 14607831.
Fujimoto M, Naka T (Dec 2003). "Regulation of cytokine signaling by SOCS family molecules". Trends in Immunology. 24 (12): 659–66. doi:10.1016/j.it.2003.10.008. PMID 14644140.
Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA (Jan 1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proceedings of the National Academy of Sciences of the United States of America. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338.
Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R (Sep 2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology. 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179.
Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS (Jul 2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation". Molecular and Cellular Biology. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL (Aug 2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin". Experimental Cell Research. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A (Apr 2005). "Suppressor of cytokine signalingسبعة inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation". The Journal of Biological Chemistry. 280 (14): 13817–23. doi:10.1074/jbc.M411596200. PMID 15677474.
Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB (Sep 2005). "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans". The Journal of Clinical Investigation. 115 (9): 2462–71. doi:10.1172/JCI23853. PMC 1190369. PMID 16127460.
Kremer BE, Adang LA, Macara IG (Sep 2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7". Cell. 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMC 2085444. PMID 17803907.