MYO1C

MYO1C
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	4BYF
المعهدات
الأسماء المستعارة	MYO1C, MMI-beta, MMIb, NMI, myr2, myosin IC
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606538 MGI: MGI:106612 HomoloGene: 32046 GeneCards: 4641
فهم الوجود الجيني
الوظيفة الجزيئية	• protein C-terminus binding; • nucleotide binding; • actin binding; • receptor binding; • cellular motor activity; • calmodulin binding; • actin-dependent ATPase activity; • ATP binding; • Ral GTPase binding; • ‏GO:0001948 ربط بروتيني; • microfilament motor activity; • actin filament binding; • microtubule motor activity; • microtubule binding;
المكونات الخلوية	• extracellular exosome; • filamentous actin; • حافة فرشاتية; • نوية; • سيتوبلازم; • مسام نووي; • إسقاط خلية; • عصارة خلوية; • نواة; • stress fiber; • stereocilium; • unconventional myosin complex; • زغيبة; • basal plasma membrane; • غشاء; • myosin I complex; • ruffle; • membrane raft; • غشاء خلوي; • myosin complex; • حويصلة سيتوبلازمية; • stereocilium membrane; • lateral plasma membrane; • ruffle membrane; • بلازم نووي; • نقاط نووية; • stereocilium bundle; • cytoplasmic vesicle membrane; • phagocytic vesicle;
العمليات الحيوية	• Fc-gamma receptor signaling pathway involved in phagocytosis; • positive regulation of protein targeting to membrane; • positive regulation of cell migration by vascular endothelial growth factor signaling pathway; • positive regulation of gene expression, epigenetic; • positive regulation of cell migration; • توجيه البروتين; • regulation of bicellular tight junction assembly; • protein transport; • protein targeting to membrane; • mRNA transport; • positive regulation of vascular endothelial growth factor signaling pathway; • positive regulation of cellular response to insulin stimulus; • positive regulation of actin filament polymerization; • نقل; • vesicle transport along actin filament; • cellular response to interferon-gamma; • microtubule-based movement;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O00159; I3L501
	Q9WTI7
	‏NM_001080779، ‏NM_001080950، ‏XM_024450768، ‏XM_024450769، ‏NM_001363855 NM_033375، ‏NM_001080779، ‏NM_001080950، ‏XM_024450768، ‏XM_024450769، ‏NM_001363855
	‏NM_001080775، ‏NM_008659، ‏NM_001370611 NM_001080774، ‏NM_001080775، ‏NM_008659، ‏NM_001370611
	‏NP_001074419، ‏NP_203693، ‏XP_024306536، ‏XP_024306537، ‏NP_001350784 NP_001074248، ‏NP_001074419، ‏NP_203693، ‏XP_024306536، ‏XP_024306537، ‏NP_001350784
	‏NP_001074244، ‏NP_032685، ‏NP_001357540 NP_001074243، ‏NP_001074244، ‏NP_032685، ‏NP_001357540
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

MYO1C‏ (Myosin IC) هوَ بروتين يُشَفر بواسطة جين MYO1C في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: MYO1C myosin IC". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.

قراءة متعمقة

Ruppert C, Godel J, Müller RT, et al. (1997). "Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains". J. Cell Sci. 108 (12): 3775–86. PMID 8719884.
Hasson T, Skowron JF, Gilbert DJ, et al. (1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motil. Cytoskeleton. 41 (4): 308–24. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.
Pestic-Dragovich L, Stojiljkovic L, Philimonenko AA, et al. (2000). "A myosin I isoform in the nucleus". Science. 290 (5490): 337–41. doi:10.1126/science.290.5490.337. PMID 11030652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Philimonenko VV, Zhao J, Iben S, et al. (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034.
Kyselá K, Philimonenko AA, Philimonenko VV, et al. (2005). "Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell". Histochem. Cell Biol. 124 (5): 347–58. doi:10.1007/s00418-005-0042-8. PMID 16133118.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Cavellán E, Asp P, Percipalle P, Farrants AK (2006). "The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription". J. Biol. Chem. 281 (24): 16264–71. doi:10.1074/jbc.M600233200. PMID 16603771.
Cisterna B, Necchi D, Prosperi E, Biggiogera M (2006). "Small ribosomal subunits associate with nuclear myosin and actin in transit to the nuclear pores". FASEB J. 20 (11): 1901–3. doi:10.1096/fj.05-5278fje. PMID 16877530.
Kahle M, Pridalová J, Spacek M, et al. (2007). "Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates". Histochem. Cell Biol. 127 (2): 139–48. doi:10.1007/s00418-006-0231-0. PMID 16957816.
Hofmann WA, Vargas GM, Ramchandran R, et al. (2006). "Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II". J. Cell. Biochem. 99 (4): 1001–9. doi:10.1002/jcb.21035. PMID 16960872.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.