ARFGEF2

ARFGEF2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	3L8N, 3SWV
المعهدات
الأسماء المستعارة	ARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605371 MGI: MGI:2139354 HomoloGene: 111880 GeneCards: 10564
فهم الوجود الجيني
الوظيفة الجزيئية	• guanyl-nucleotide exchange factor activity; • GABA receptor binding; • ARF guanyl-nucleotide exchange factor activity; • myosin binding; • ‏GO:0001948 ربط بروتيني; • protein kinase A regulatory subunit binding;
المكونات الخلوية	• سيتوبلازم; • recycling endosome; • عصارة خلوية; • جسيم داخلي; • جهاز غولجي; • إسقاط خلية; • غشاء; • Golgi membrane; • dendritic spine; • تشابك عصبي; • microtubule organizing center; • موصل خلوي; • trans-Golgi network; • تغصن; • symmetric synapse; • asymmetric synapse; • perinuclear region of cytoplasm; • هيكل خلوي; • حويصلة سيتوبلازمية; • axonemal microtubule;
العمليات الحيوية	• endomembrane system organization; • intracellular signal transduction; • regulation of ARF protein signal transduction; • endosome organization; • receptor recycling; • positive regulation of tumor necrosis factor production; • protein transport; • Golgi to plasma membrane transport; • إخراج خلوي; • نقل; • regulation of molecular function; • vesicle-mediated transport;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9Y6D5
	A2A5R2
	‏NM_006420 XM_005260252، ‏NM_006420
	‏XM_006500483، ‏XM_006500484، ‏XM_030252278 NM_001085495، ‏XM_006500483، ‏XM_006500484، ‏XM_030252278
	‏XP_005260309 NP_006411، ‏XP_005260309
	‏XP_006500546، ‏XP_006500547، ‏XP_030108138 NP_001078964، ‏XP_006500546، ‏XP_006500547، ‏XP_030108138
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ARFGEF2‏ (ADP ribosylation factor guanine nucleotide exchange factor 2) هوَ بروتين يُشَفر بواسطة جين ARFGEF2 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
^ "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)". مؤرشف من الأصل فيستة مارس 2010.

قراءة متعمقة

Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". Methods in Enzymology. 345: 397–404. doi:10.1016/S0076-6879(02)45032-X. PMID 11665623.
Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K (Mar 2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". The Journal of Biological Chemistry. 277 (11): 9468–73. doi:10.1074/jbc.M112427200. PMID 11777925.
Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K (Jun 2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochemical and Biophysical Research Communications. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.
Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA (Jan 2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex". Nature Genetics. 36 (1): 69–76. doi:10.1038/ng1276. PMID 14647276.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2784–9. doi:10.1073/pnas.0409871102. PMC 549493. PMID 15705715.
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V (Jan 2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". The Journal of Comparative Neurology. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ (Mar 2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles". The Journal of Biological Chemistry. 282 (13): 9591–9. doi:10.1074/jbc.M607122200. PMID 17276987.
Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMC 1805514. PMID 17360629.