LEKTI

SPINK5
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1H0Z, 1HDL, 1UUC, 1UVF, 1UVG
المعهدات
الأسماء المستعارة	SPINK5, LEKTI, LETKI, NETS, NS, VAKTI, serine peptidase inhibitor, Kazal type 5, serine peptidase inhibitor Kazal type 5
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605010 MGI: MGI:1919682 HomoloGene: 4987 GeneCards: 11005
فهم الوجود الجيني
الوظيفة الجزيئية	• peptidase inhibitor activity; • serine-type endopeptidase inhibitor activity;
المكونات الخلوية	• سيتوبلازم; • عصارة خلوية; • endoplasmic reticulum membrane; • قشرة الخلية; • شبكة إندوبلازمية; • perinuclear region of cytoplasm; • epidermal lamellar body; • منطقة خارج الخلية; • intracellular membrane-bounded organelle;
العمليات الحيوية	• epidermal cell differentiation; • negative regulation of proteolysis; • negative regulation of serine-type peptidase activity; • negative regulation of peptidase activity; • epithelial cell differentiation; • hair cell differentiation; • extracellular matrix organization; • negative regulation of antibacterial peptide production; • negative regulation of immune response; • regulation of cell adhesion; • negative regulation of angiogenesis; • negative regulation of serine-type endopeptidase activity; • regulation of T cell differentiation; • cornification; • regulation of timing of anagen;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9NQ38
	Q148R4
	‏NM_001127698، ‏NM_001127699، ‏NM_006846 XM_011537551، ‏NM_001127698، ‏NM_001127699، ‏NM_006846
	‏XM_006526279، ‏XM_006526280 NM_001081180، ‏XM_006526279، ‏XM_006526280
	‏NP_001121171، ‏NP_006837، ‏XP_011535853 NP_001121170، ‏NP_001121171، ‏NP_006837، ‏XP_011535853
	‏XP_006526342، ‏XP_006526343 NP_001074649، ‏XP_006526342، ‏XP_006526343
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

LEKTI‏ (Serine peptidase inhibitor, Kazal type 5) هوَ بروتين يُشَفر بواسطة جين LEKTI في الإنسان.

يُسمى أيضًا النوع الخامس من كازال مثبط بروتياز السيرين.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: SPINK5 serine peptidase inhibitor, Kazal type 5". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Magert HJ, Standker L, Kreutzmann P, Zucht HD, Reinecke M, Sommerhoff CP, Fritz H, Forssmann WG (Aug 1999). "LEKTI, a novel 15-domain type of human serine proteinase inhibitor". J Biol Chem. 274 (31): 21499–502. doi:10.1074/jbc.274.31.21499. PMID 10419450.

قراءة متعمقة

Norgett EE, Kelsell DP (2002). "SPINK5: both rare and common skin disease". Trends in Molecular Medicine. 8 (1): 7. doi:10.1016/S1471-4914(01)02228-6. PMID 11796258.
Mägert HJ, Kreutzmann P, Ständker L, et al. (2002). "LEKTI: a multidomain serine proteinase inhibitor with pathophysiological relevance". Int. J. Biochem. Cell Biol. 34 (6): 573–6. doi:10.1016/S1357-2725(01)00179-0. PMID 11943586.
Walden M, Kreutzmann P, Drögemüller K, et al. (2003). "Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI". Biol. Chem. 383 (7–8): 1139–41. doi:10.1515/BC.2002.124. PMID 12437098.
Chavanas S, Garner C, Bodemer C, et al. (2000). "Localization of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping". Am. J. Hum. Genet. 66 (3): 914–21. doi:10.1086/302824. PMC 1288172. PMID 10712206.
Chavanas S, Bodemer C, Rochat A, et al. (2000). "Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome". Nat. Genet. 25 (2): 141–2. doi:10.1038/75977. PMID 10835624.
Sprecher E, Chavanas S, DiGiovanna JJ, et al. (2001). "The spectrum of pathogenic mutations in SPINK5 in 19 families with Netherton syndrome: implications for mutation detection and first case of prenatal diagnosis". J. Invest. Dermatol. 117 (2): 179–87. doi:10.1046/j.1523-1747.2001.01389.x. PMID 11511292.
Walley AJ, Chavanas S, Moffatt MF, et al. (2001). "Gene polymorphism in Netherton and common atopic disease". Nat. Genet. 29 (2): 175–8. doi:10.1038/ng728. PMID 11544479.
Ahmed A, Kandola P, Ziada G, Parenteau N (2002). "Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium". J. Protein Chem. 20 (4): 273–8. doi:10.1023/A:1010902815953. PMID 11594460.
Bitoun E, Chavanas S, Irvine AD, et al. (2002). "Netherton syndrome: disease expression and spectrum of SPINK5 mutations in 21 families". J. Invest. Dermatol. 118 (2): 352–61. doi:10.1046/j.1523-1747.2002.01603.x. PMID 11841556.
Komatsu N, Takata M, Otsuki N, et al. (2002). "Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides". J. Invest. Dermatol. 118 (3): 436–43. doi:10.1046/j.0022-202x.2001.01663.x. PMID 11874482.
Bitoun E, Micheloni A, Lamant L, et al. (2004). "LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome". Hum. Mol. Genet. 12 (19): 2417–30. doi:10.1093/hmg/ddg247. PMID 12915442.
Nishio Y, Noguchi E, Shibasaki M, et al. (2004). "Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese". Genes Immun. 4 (7): 515–7. doi:10.1038/sj.gene.6363889. PMID 14551605.
Raghunath M, Tontsidou L, Oji V, et al. (2004). "SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases". J. Invest. Dermatol. 123 (3): 474–83. doi:10.1111/j.0022-202X.2004.23220.x. PMID 15304086.
Tidow H, Lauber T, Vitzithum K, et al. (2004). "The solution structure of a chimeric LEKTI domain reveals a chameleon sequence". Biochemistry. 43 (35): 11238–47. doi:10.1021/bi0492399. PMID 15366933.
Yang T, Liang D, Koch PJ, et al. (2004). "Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice". Genes Dev. 18 (19): 2354–8. doi:10.1101/gad.1232104. PMC 522985. PMID 15466487.
Ishida-Yamamoto A, Deraison C, Bonnart C, et al. (2005). "LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum". J. Invest. Dermatol. 124 (2): 360–6. doi:10.1111/j.0022-202X.2004.23583.x. PMID 15675955.