CYP26A1

CYP26A1
المعهدات
الأسماء المستعارة	CYP26A1, CP26, CYP26, P450RAI, P450RAI1, cytochrome P450 family 26 subfamily A member 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602239 MGI: MGI:1096359 HomoloGene: 37349 GeneCards: 1592
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط أيون الحديد; • oxygen binding; • oxidoreductase activity; • retinoic acid binding; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • ربط أيون فلزي; • monooxygenase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; • retinoic acid 4-hydroxylase activity;
المكونات الخلوية	• organelle membrane; • endoplasmic reticulum membrane; • شبكة إندوبلازمية; • غشاء; • intracellular membrane-bounded organelle;
العمليات الحيوية	• negative regulation of retinoic acid receptor signaling pathway; • retinoic acid catabolic process; • oxidation-reduction process; • vitamin metabolic process; • xenobiotic metabolic process; • sterol metabolic process; • response to retinoic acid; • response to vitamin A; • retinoic acid metabolic process; • تطور الكلى;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O43174
	O55127
	‏NM_000783 NM_057157، ‏NM_000783
	‏XM_017318053 NM_007811، ‏XM_017318053
	‏NP_476498 NP_000774، ‏NP_476498
	‏XP_017173542 NP_031837، ‏XP_017173542
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

CYP26A1‏ (Cytochrome P450 family 26 subfamily A member 1) هوَ بروتين يُشَفر بواسطة جين CYP26A1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M (July 1997). "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". The Journal of Biological Chemistry. 272 (30): 18538–41. doi:10.1074/jbc.272.30.18538. PMID 9228017.
^ White JA, Beckett B, Scherer SW, Herbrick JA, Petkovich M (March 1998). "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics. 48 (2): 270–2. doi:10.1006/geno.1997.5157. PMID 9521883.
^ "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

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Sonneveld E, van den Brink CE, van der Leede BM, Schulkes RK, Petkovich M, van der Burg B, van der Saag PT (August 1998). "Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells". Cell Growth & Differentiation. 9 (8): 629–37. PMID 9716180.
Trofimova-Griffin ME, Juchau MR (November 1998). "Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues". Biochemical and Biophysical Research Communications. 252 (2): 487–91. doi:10.1006/bbrc.1998.9659. PMID 9826557.
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Ozpolat B, Mehta K, Lopez-Berestein G (October 2005). "Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells". Leukemia & Lymphoma. 46 (10): 1497–506. doi:10.1080/10428190500174737. PMID 16194896.
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Quere R, Baudet A, Cassinat B, Bertrand G, Marti J, Manchon L, Piquemal D, Chomienne C, Commes T (May 2007). "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity". Blood. 109 (10): 4450–60. doi:10.1182/blood-2006-10-051086. PMID 17218384.
Lee SJ, Perera L, Coulter SJ, Mohrenweiser HW, Jetten A, Goldstein JA (March 2007). "The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system". Pharmacogenetics and Genomics. 17 (3): 169–80. doi:10.1097/FPC.0b013e32801152d6. PMC 2393551. PMID 17460545.