PDCD4

PDCD4
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ
المعهدات
الأسماء المستعارة	PDCD4, H731, programmed cell death أربعة (neoplastic transformation inhibitor), programmed cell death 4
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 608610 MGI: MGI:107490 HomoloGene: 7879 GeneCards: 27250
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني; • RNA binding;
المكونات الخلوية	• سيتوبلازم; • نواة; • عصارة خلوية; • بلازم نووي;
العمليات الحيوية	• cell aging; • regulation of protein metabolic process; • negative regulation of cell cycle; • negative regulation of apoptotic process; • negative regulation of transcription, DNA-templated; • negative regulation of JUN kinase activity; • positive regulation of smooth muscle cell apoptotic process; • negative regulation of myofibroblast differentiation; • استماتة; • positive regulation of endothelial cell apoptotic process; • BMP signaling pathway; • epithelial to mesenchymal transition involved in cardiac fibroblast development; • negative regulation of vascular smooth muscle cell differentiation; • positive regulation of inflammatory response; • cellular response to lipopolysaccharide; • negative regulation of cytokine production involved in inflammatory response; • positive regulation of NIK/NF-kappaB signaling; • interleukin-12-mediated signaling pathway; • negative regulation of vascular smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell apoptotic process;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q53EL6; Q5VZS7
	Q61823
	‏NM_001199492، ‏NM_014456 NM_145341، ‏NM_001199492، ‏NM_014456
	‏NM_001168492، ‏NM_011050، ‏XM_006526762، ‏XM_030250768، ‏XM_030250769، ‏XM_030250770 NM_001168491، ‏NM_001168492، ‏NM_011050، ‏XM_006526762، ‏XM_030250768، ‏XM_030250769، ‏XM_030250770
	‏NP_055271، ‏NP_663314 NP_001186421، ‏NP_055271، ‏NP_663314
	‏NP_001161964، ‏NP_035180، ‏XP_006526825، ‏XP_030106628، ‏XP_030106629، ‏XP_030106630 NP_001161963، ‏NP_001161964، ‏NP_035180، ‏XP_006526825، ‏XP_030106628، ‏XP_030106629، ‏XP_030106630
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

PDCD4‏ (Programmed cell death 4) هوَ بروتين يُشَفر بواسطة جين PDCD4 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ EntrezGene 27250
^ Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death أربعة (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
^ Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of Immunology. 161 (7): 3493–500. PMID 9759869.

قراءة متعمقة

Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B (2004). "Programmed Cell Death Protein أربعة (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells". Annals of the New York Academy of Sciences. 1014: 220–1. doi:10.1196/annals.1294.024. PMID 15153438.
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z (1999). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody". Pathology International. 49 (12): 1067–77. doi:10.1046/j.1440-1827.1999.00995.x. PMID 10632927.
Soejima, H.; Miyoshi, O.; Yoshinaga, H.; Masaki, Z.; Ozaki, I.; Kajiwara, S.; Niikawa, N.; Matsuhashi, S.; Mukai, T. (1999). "Assignment¹ of the programmed cell death أربعة gene (PDCD4) to human chromosome band 10q24 by in situ hybridization". Cytogenetic and Genome Research. 87: 113–4. doi:10.1159/000015408.
Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
Chen Y, Knösel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis". The Journal of Pathology. 200 (5): 640–6. doi:10.1002/path.1378. PMID 12898601.
Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH (2004). "A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A". Molecular and Cellular Biology. 24 (9): 3894–906. doi:10.1128/MCB.24.9.3894-3906.2004. PMC 387765. PMID 15082783.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B (2004). "Programmed cell death protein أربعة suppresses CDK1/cdc2 via induction of p21Waf1/Cip1". AJP: Cell Physiology. 287 (6): C1541–6. doi:10.1152/ajpcell.00025.2004. PMID 15317660.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2004). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y (2005). "Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein". Cancer Research. 65 (24): 11282–6. doi:10.1158/0008-5472.CAN-05-3469. PMID 16357133.
Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH (2006). "Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion". Molecular and Cellular Biology. 26 (4): 1297–306. doi:10.1128/MCB.26.4.1297-1306.2006. PMC 1367180. PMID 16449643.