FZR1

FZR1
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	4UI9
المعهدات
الأسماء المستعارة	FZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 603619 MGI: MGI:1926790 HomoloGene: 9444 GeneCards: 51343
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني; • anaphase-promoting complex binding; • ubiquitin-protein transferase activator activity;
المكونات الخلوية	• سيتوبلازم; • عصارة خلوية; • غشاء نووي; • بلازم نووي; • anaphase-promoting complex; • نواة;
العمليات الحيوية	• positive regulation of protein catabolic process; • negative regulation of cell aging; • regulation of meiotic nuclear division; • cellular response to DNA damage stimulus; • انقسام خلوي; • protein K11-linked ubiquitination; • lens fiber cell differentiation; • protein ubiquitination; • ضبط زيادي للتكاثر الخلوي; • دورة الخلية; • anaphase-promoting complex-dependent catabolic process; • ترميم الدنا; • positive regulation of ubiquitin protein ligase activity; • signal transduction involved in G2 DNA damage checkpoint; • regulation of mitotic cell cycle phase transition; • ubiquitin-dependent protein catabolic process;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9UM11
	Q9R1K5
	‏NM_001136198، ‏NM_016263، ‏XM_005259573، ‏XM_017026863، ‏XR_001753699 NM_001136197، ‏NM_001136198، ‏NM_016263، ‏XM_005259573، ‏XM_017026863، ‏XR_001753699
	NM_019757
	‏NP_001129670، ‏NP_057347، ‏XP_005259630، ‏XP_016882352 NP_001129669، ‏NP_001129670، ‏NP_057347، ‏XP_005259630، ‏XP_016882352
	NP_062731
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FZR1‏ (Fizzy and cell division cycle 20 related 1) هوَ بروتين يُشَفر بواسطة جين FZR1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (Oct 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Mol Cell Biol. 20 (20): 7613–7623. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657.
^ Fang G, Yu H, Kirschner MW (Sep 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Mol Cell. 2 (2): 163–171. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353.

قراءة متعمقة

Kramer ER, Gieffers C, Hölzl G, et al. (1999). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Curr. Biol. 8 (22): 1207–S4. doi:10.1016/S0960-9822(07)00510-6. PMID 9811605.
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Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–11322. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
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Bembenek J, Yu H (2002). "Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a". J. Biol. Chem. 276 (51): 48237–42. doi:10.1074/jbc.M108126200. PMID 11598127.
Stroschein SL, Bonni S, Wrana JL, Luo K (2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. 15 (21): 2822–36. doi:10.1101/gad.912901. PMC 312804. PMID 11691834.
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Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–1468. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
Wei W, Ayad NG, Wan Y, et al. (2004). "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex". Nature. 428 (6979): 194–198. doi:10.1038/nature02381. PMID 15014503.
Listovsky T, Oren YS, Yudkovsky Y, et al. (2005). "Mammalian Cdh1/Fzr mediates its own degradation". EMBO J. 23 (7): 1619–1626. doi:10.1038/sj.emboj.7600149. PMC 391060. PMID 15029244.
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Nourry C, Maksumova L, Pang M, et al. (2005). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biol. 5: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kraft C, Vodermaier HC, Maurer-Stroh S, et al. (2005). "The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates". Mol. Cell. 18 (5): 543–553. doi:10.1016/j.molcel.2005.04.023. PMID 15916961.