ڤيروس ماربورگ
| Marburg virus | |
|---|---|
| Transmission electron micrograph of the Marburg virus | |
| تصنيف الفيروسات | |
| Group: | Group V ((−)ssRNA) |
| Order: | Mononegavirales |
| Family: | Filoviridae |
| Genus: | 'Marburgvirus' |
| Type species | |
|
Marburg marburgvirus | |
ڤيروس ماربورگ (بالإنگليزية: Marburg virus؛ النطق: // ) هوحمى نزفية ڤيروسية لوحظ لأول مرة ووُصِف أثناء أوبئة ضيقة الانتشار في المدينتين الألمانيتين ماربورگ وفرانكفورت والعاصمة اليوغسلاڤية بلگراد في عقد 1960. فقد تعرض العمال بالصدفة لأنسجة قرود عبلنج سوداني مصابة (Chlorocebus aethiops) في المصنع الرئيسي السابق بالمدينة، Behringwerke، التي كانت آنذاك جزءاً من هوكست، and today of CSL Behring. أثناء تلك التفشيات، 31 إنسان أصبحوا مصابين وسبعة منهم توفوا. ڤيروس ماربورگ (MARV) يسبب سقماً شديداً في البشر والرئيسيات من غير البشر في شكل حمى نزفية ڤيروسية. MARV is a Select Agent،WHO Risk Group أربعة Pathogen (requiring احتواء مساوي للمستوى الرابع من السلامة الحيوية),ممراض من أولوية التصنيف أ من المعهد الوطني للحساسية والأمراض المعدية في NIH،عامل ارهاب حيوي من الفئة أ حسب مراكز السيطرة على الأمراض والوقاية منها، وهومدرج كعامل بيولوجي للتحكم في الصادرات في مجموعة أستراليا.
سمات ضم الڤيروس
A virus that fulfills the criteria for being a member of the species Marburg marburgvirus is a ڤيروس ماربورگ if its genome diverges from that of the prototype Marburg marburgvirus, تنويعة من ڤيروس ماربورگ Musoke (MARV/Mus), by <10% at the nucleotide level.
السقم
ڤيروس ماربورگ هوواحد من اثنين من ڤيروسات ماربورگ marburgviruses التي تسبب سقم ڤيروس ماربورگ (MVD) في البشر (وفي الأدبيات كثيراً ما يشار غليه بإسم حمى ماربورگ النزفية Marburg hemorrhagic fever، أوMHF). وفي الماضي، تسبب سقم ڤيروس ماربورگ في التفشيات التالية:
| السنة | المسقط الجغرافي | حالات/وفيات بشرية (معدل حالات الوفاة) |
| 1967 | ماربورگ وفرانكفورت، ألمانيا الغربية، وبلگراد، يوغسلاڤيا | 7/31 (23%) |
| 1975 | رودسيا وجوهانسبرگ، جنوب أفريقيا | 1/3 (33%) |
| 1980 | كنيا | 1/2 (50%) |
| 1987 | كنيا | 1/1 (100%) |
| 1988 | كولتسوڤو، الاتحاد السوڤيتي | 1/1 (100%) [laboratory accident] |
| 1990 | كولتسوڤو، الاتحاد السوڤيتي | 0/1 (0%) [laboratory accident] |
| 1998–2000 | دوربا، وواتسا، جمهورية الكونغوالديمقراطية | ? (A total of 154 cases and 128 deaths of marburgvirus infection were recorded during this outbreak. The case fatality was 83%. Two different marburgviruses, MARV and Ravn virus (RAVV), cocirculated and caused disease. It has never been published how many cases and deaths were due to MARV or RAVV infection) |
| 2004–2005 | أنگولا | 227/252 (90%) |
| 2007 | اوغندا | 1/3 (33%) |
| 2008 | اوغندا، هولندا | 1/1 (100%) |
| 2012 | اوغندا | 9/18 (50%) |
فهم الڤيروسات
الجينوم
البنية
التناسخ
أبحاث اللقاح
In 2009, expanded clinical trials of an Ebola and Marburg vaccine began in Africa. No vaccine to date has been approved for use in the US.
الهامش
- ^ خطأ استشهاد: وسم
<ref>غير سليم؛ لا نص تم توفيره للمراجع المسماةKuhnArch - ^ US Animal and Plant Health Inspection Service (APHIS) و(CDC). "National Select Agent Registry (NSAR)". Retrieved 2011-10-16.
- ^ US Department of Health and Human Services. "Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition". Retrieved 2011-10-16.
- ^ US National Institutes of Health (NIH), US National Institute of Allergy and Infectious Diseases (NIAID). "Biodefense — NIAID Category A, B, and C Priority Pathogens". Retrieved 2011-10-16.
- ^ US Centers for Disease Control and Prevention (CDC). "Bioterrorism Agents/Diseases". Retrieved 2011-10-16.
- ^ The Australia Group. "List of Biological Agents for Export Control". Retrieved 2011-10-16.
-
^ خطأ استشهاد: وسم
<ref>غير سليم؛ لا نص تم توفيره للمراجع المسماةSiegert1967 -
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^ "Marburg hemorrhagic fever outbreak continues in Uganda". 2012. Unknown parameter
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للاستزادة
- Klenk, Hans-Dieter (1999), Marburg and Ebola Viruses. Current Topics in Microbiology and Immunology, vol. 235, Berlin, Germany: Springer-Verlag, ISBN 978-3-540-64729-4
- Klenk, Hans-Dieter; Feldmann, Heinz (2004), Ebola and Marburg Viruses: Molecular and Cellular Biology, Wymondham, Norfolk, UK: Horizon Bioscience, ISBN 978-0-9545232-3-7
- Kuhn, Jens H. (2008), Filoviruses: A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies. Archives of Virology Supplement, vol. 20, Vienna, Austria: SpringerWienNewYork, ISBN 978-3-211-20670-6
- Martini, G. A.; Siegert, R. (1971). Marburg Virus Disease. Berlin, Germany: Springer-Verlag. ISBN .
- Ryabchikova, Elena I.; Price, Barbara B. (2004), Ebola and Marburg Viruses: A View of Infection Using Electron Microscopy, Columbus, Ohio, USA: Battelle Press, ISBN 978-1-57477-131-2
وصلات خارجية
 |
مشاع الفهم فيه ميديا متعلقة بموضوع Marburg virus. |
- International Committee on Taxonomy of Viruses (ICTV)
