Ethosuximide


Ethosuximide {{{English
الاسم النظامي (أيوپاك)
الاسم النظامي (أيوپاك)
3-ethyl-3-methyl-pyrrolidine-2,5-dione
المعينات Identifiers
رقم CAS	77-67-8
كود ATC	N03AD01
PubChem	3291
بنك العقاقير	APRD00318
بيانات كيميائية
الصيغة	₇₁₁₂
كتلة جزيئية	141.168 g/mol
بيانات الحركية الدوائية Pharmacokinetic
التوافر الحيوي	93%^[1]
الأيض	Hepatic (CYP3A4, CYP2E1)
عمر النصف	53 hours
اخراج	Renal (20%)
اعتبارات علاجية
فئة السلامة أثناء الحمل	D (Au, U.S.)
الوضع القانوني	℞-only (U.S.)
المسارات	Oral

الاستعمالات

التصريح باستعمال الدواء

عدم التصريح باستعمال الدواء

الجرعات

اتاحة الدواء

نظرية عمل الدواء

التأثيرات الجانبية

الجهاز العصبي المركزى

Common

drowsiness
mental confusion
insomnia
nervousness
headache
euphoria
ataxia
hiccups
impaired concentration
irritability
hyperactivity
loss of taste
night terrors

Rare

paranoid psychosis
increased libido
exacerbation of depression

Gastrointestinal

dyspepsia
vomiting
nausea
cramps
constipation
diarrhea
stomach pain
loss of appetite
weight loss
gingival hyperplasia
swelling of tongue

الهامش

Sources

Ethosuximide Internet Mental Health.
MedlinePlus Drug Information: Ethosuximide Oral
Zarontin Pfizer.
Zarontin Drug information, published studies and current trials

Notes

Patsalos, P. N. (2005). "Properties of Antiepileptic Drugs in the Treatment of Idiopathic Generalized Epilepsies". Epilepsia. 46 (s9): 140–144. doi:10.1111/j.1528-1167.2005.00326.x. PMID 16302888. Unknown parameter |month= ignored (help)
Pharmaceutical Associates, Incorporated (2000). "Ethosuximide Approval Label" (PDF). Label and Approval History. Food and Drug Administration Center for Drug Evaluation and Research. Retrieved 2006-02-05.
"Drugs used in generalized seizures." Katzung, B. Basic and Clinical Pharmacology. 9th Ed. 2003. Lange Medical Books/McGraw-Hill.0071410929.
Andrulonis, P. A. (1980). "Preliminary data on ethosuximide and the Episodic dyscontrol syndrome". American Journal of Psychiatry. 137 (11): 1455–6. PMID 7435689. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
Coulter DA, Huguenard JR, Prince DA. "Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons." Neurosci Lett. 1989 Mar 13;98(1):74-8. PMID 2710401
"Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons." Annals of Neurology. 1989 Jun;25(6):582-93. PMID 2545161
Coulter DA, Huguenard JR, Prince DA. "Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction." British Journal of Pharmacology. 1990 Aug;100(4):800-6. PMID 2169941
Kostyuk PG, Molokanova EA, Pronchuk NF, Savchenko AN, Verkhratsky AN. "Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons." Neuroscience. 1992 Dec;51(4):755-8. PMID 1336826
Herrington J, Lingle CJ (1992). "Kinetic and pharmacological properties of low voltage-activated Ca2+ current in rat clonal (GH3) pituitary cells". Journal of Neurophysiology. 68 (1): 213–32. PMID 1325546. Unknown parameter |month= ignored (help)
Sayer RJ, Brown AM, Schwindt PC, Crill WE. "Calcium currents in acutely isolated human neocortical neurons." Journal of Neurophysiology. 1993 May;69(5):1596-606. PMID 8389832 Fulltext
Todorovic SM, Lingle CJ (1998). "Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents". Journal of Neurophysiology. 79 (1): 240–52. PMID 9425195.
Leresche N, Parri HR, Erdemli G, Guyon A, Turner JP, Williams SR, Asprodini E, Crunelli V (1998). "On the action of the anti-absence drug ethosuximide in the rat and cat thalamus". Journal of Neuroscience. 18 (13): 4842–53. PMID 9634550.CS1 maint: multiple names: authors list (link)
Gomora JC, Daud AN, Weiergraber M, Perez-Reyes E (2001). "Block of cloned human T-type calcium channels by succinimide antiepileptic drugs". Molecular Pharmacology. 60 (5): 1121–32. PMID 11641441.CS1 maint: multiple names: authors list (link)
Bourgeois, BF (1988). "Combination of valproate and ethosuximide: antiepileptic and neurotoxic interaction". The Journal of Pharmacology and Experimental Therapeutics. 247 (3): 1128–32. PMID 3144596. Unknown parameter |month= ignored (help)