RGS7 (Regulator of G-protein-signaling 7) هوَ بروتين يُشَفر بواسطة جين RGS7 في الإنسان.
الوظيفة
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
الأهمية السريرية
هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.
المراجع
^Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815.
^Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1–3): 33–46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673. مؤرشف من الأصل في 13 يوليو2018.
^"Entrez Gene: RGS7 regulator of G-protein signalling 7". مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". J. Neurochem. 70 (5): 1964–72. doi:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents". J. Biol. Chem. 274 (14): 9899–904. doi:10.1074/jbc.274.14.9899. PMID 10092682.
Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signalingستة and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G (2000). "14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity". J. Biol. Chem. 275 (36): 28167–72. doi:10.1074/jbc.M002905200. PMID 10862767.
Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR (2000). "RGS7 is palmitoylated and exists as biochemically distinct forms". J. Neurochem. 75 (5): 2103–12. doi:10.1046/j.1471-4159.2000.0752103.x. PMID 11032900.
Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF (2001). "Nuclear localization of G protein betaخمسة and regulator of G protein signalingسبعة in neurons and brain". J. Biol. Chem. 276 (13): 10284–9. doi:10.1074/jbc.M009247200. PMID 11152459.
Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E (2002). "Interaction of 14-3-3 protein with regulator of G protein signalingسبعة is dynamically regulated by tumor necrosis factor-alpha". J. Biol. Chem. 277 (36): 32954–62. doi:10.1074/jbc.M200859200. PMID 12077120.
Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.
Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ (2003). "G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction". J. Biol. Chem. 278 (23): 21307–13. doi:10.1074/jbc.M212884200. PMID 12670932.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources" (PDF). Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. مؤرشف من الأصل (PDF) في 20 يوليو2018.
Takida S, Fischer CC, Wedegaertner PB (2005). "Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo". Mol. Pharmacol. 67 (1): 132–9. doi:10.1124/mol.104.003418. PMC 1405920. PMID 15496508.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ (2006). "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism". J. Biol. Chem. 281 (38): 28222–31. doi:10.1074/jbc.M604428200. PMID 16867977.
تاريخ النشر:
2020-06-02 12:53:29
التصنيفات:
جينات على كروموسوم 1, صفحات تستعمل قالبا ببيانات مكررة, مقالات بها أقسام فارغة منذ يوليو 2018, جميع المقالات التي بها أقسام فارغة, صفحات بها بيانات ويكي بيانات, صفحات تستخدم خاصية P639, معرفات مركب كيميائي, بوابة الكيمياء الحيوية/مقالات متعلقة, بوابة علم الأحياء الخلوي والجزيئي/مقالات متعلقة, بوابة طب/مقالات متعلقة, جميع المقالات التي تستخدم شريط بوابات, جميع مقالات البذور, بذرة جين على كروموسوم 1