ZC3H12A

ZC3H12A
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	3V32, 3V33, 3V34
المعهدات
الأسماء المستعارة	ZC3H12A, MCPIP, MCPIP1, dJ423B22.1, zinc finger CCCH-type containing 12A, Reg1, MCPIP-1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 610562 MGI: MGI:2385891 HomoloGene: 11824 GeneCards: 80149
فهم الوجود الجيني
الوظيفة الجزيئية	• miRNA binding; • chromatin binding; • ربط أيون فلزي; • ribonuclease activity; • ‏GO:0001948 ربط بروتيني; • nuclease activity; • endonuclease activity; • mRNA binding; • نشاط هيدرولاز; • ribosome binding; • mRNA 3'-UTR binding; • mRNA 3'-UTR AU-rich region binding; • ربط دي إذا إي; • RNA binding; • endoribonuclease activity; • exoribonuclease activity; • thiol-dependent ubiquitin-specific protease activity; • RNA stem-loop binding;
المكونات الخلوية	• سيتوبلازم; • بلازم نووي; • هيكل خلوي; • نواة; • extrinsic component of endoplasmic reticulum membrane; • شبكة إندوبلازمية; • rough endoplasmic reticulum membrane; • rough endoplasmic reticulum; • P-body; • غشاء; • حبيبة رنا; • macromolecular complex;
العمليات الحيوية	• positive regulation of p38MAPK cascade; • cellular response to virus; • تمايز خلوي; • positive regulation of cell death; • positive regulation of autophagy; • negative regulation of interleukin-6 production; • positive regulation of lipid storage; • negative regulation of macrophage activation; • cellular response to tumor necrosis factor; • negative regulation of gene expression; • positive regulation of angiogenesis; • negative regulation of production of miRNAs involved in gene silencing by miRNA; • positive regulation of endothelial cell migration; • نمومتعدد الخلايا; • protein deubiquitination; • positive regulation of gene expression; • positive regulation of reactive oxygen species metabolic process; • protein oligomerization; • توليد الأوعية; • تنظيم التعبير الجيني; • positive regulation of protein import into nucleus; • negative regulation by host of viral genome replication; • negative regulation of tumor necrosis factor production; • positive regulation of miRNA catabolic process; • negative regulation of NF-kappaB transcription factor activity; • positive regulation of defense response to virus by host; • استماتة; • RNA phosphodiester bond hydrolysis, endonucleolytic; • immune system process; • negative regulation of muscle cell apoptotic process; • negative regulation of tumor necrosis factor secretion; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • نسخ الدنا; • positive regulation of fat cell differentiation; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay; • defense response to virus; • cellular response to glucose starvation; • nervous system development; • negative regulation of cytokine production involved in inflammatory response; • cellular response to sodium arsenite; • negative regulation of interleukin-6 secretion; • ضبط نسخ الدنا; • negative regulation of protein phosphorylation; • cellular response to ionomycin; • negative regulation of interferon-gamma secretion; • negative regulation of interleukin-1 beta secretion; • positive regulation of mRNA catabolic process; • cellular response to lipopolysaccharide; • cellular response to oxidative stress; • RNA phosphodiester bond hydrolysis; • negative regulation of nitric oxide biosynthetic process; • cellular response to interleukin-1; • positive regulation of protein deubiquitination; • cellular response to chemokine; • inflammatory response; • 3'-UTR-mediated mRNA destabilization; • negative regulation of cardiac muscle contraction; • positive regulation of execution phase of apoptosis; • RNA phosphodiester bond hydrolysis, exonucleolytic; • cellular response to DNA damage stimulus; • immune response-activating signal transduction; • negative regulation of NIK/NF-kappaB signaling; • T cell receptor signaling pathway; • negative regulation of T-helper 17 cell differentiation;
	المصادر:Amigo / QuickGO
أورثولوج
	Q5D1E8
	Q5D1E7
	‏NM_025079، ‏NM_001323550، ‏NM_001323551، ‏XR_001737436 XM_011542198، ‏NM_025079، ‏NM_001323550، ‏NM_001323551، ‏XR_001737436
	NM_153159
	‏NP_001310480، ‏NP_079355، ‏XP_011540500 NP_001310479، ‏NP_001310480، ‏NP_079355، ‏XP_011540500
	NP_694799
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ZC3H12A‏ (Zinc finger CCCH-type containing 12A) هوَ بروتين يُشَفر بواسطة جين ZC3H12A في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: Zinc finger CCCH-type containing 12A". مؤرشف من الأصل فيخمسة ديسمبر 2010.

قراءة متعمقة

Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE, Fu M (2008). "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages". The Journal of Biological Chemistry. 283 (10): 6337–46. doi:10.1074/jbc.M707861200. PMID 18178554.