GATA5

GATA5
المعهدات
الأسماء المستعارة	GATA5, GATAS, bB379O24.1, GATA binding protein 5, CHTD5
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 611496 MGI: MGI:109497 HomoloGene: 32031 GeneCards: 140628
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إذا إي; • sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • RNA polymerase II transcription factor binding; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • ‏GO:0001077، ‏GO:0001212، ‏GO:0001213، ‏GO:0001211، ‏GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • ربط أيون الزنك; • chromatin binding; • ربط أيون فلزي; • ‏GO:0001158 core promoter proximal region sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • ‏GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • ‏GO:0001948 ربط بروتيني;
المكونات الخلوية	• transcription factor complex; • بلازم نووي; • نواة; • nuclear chromatin;
العمليات الحيوية	• ضبط نسخ الدنا; • cellular response to BMP stimulus; • تجلط الدم; • نسخ الدنا; • positive regulation of transcription, DNA-templated; • intestinal epithelial cell differentiation; • transcription from RNA polymerase II promoter; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • aortic valve morphogenesis; • endocardial cushion fusion; • negative regulation of cardiac muscle hypertrophy; • positive regulation of gene expression; • negative regulation of gene expression; • positive regulation of Notch signaling pathway involved in heart induction; • positive regulation of cardiac endothelial to mesenchymal transition; • positive regulation of transcription from RNA polymerase II promoter involved in heart development; • heart development; • تشكل العضوالحيواني; • تكون الأنسجة; • cell development; • anatomical structure formation involved in morphogenesis; • digestive tract development; • cardiac muscle tissue development; • circulatory system development;
	المصادر:Amigo / QuickGO
أورثولوج
	Q9BWX5
	P97489
	‏NM_080473 XM_006723699، ‏NM_080473
	‏XM_006500554 NM_008093، ‏XM_006500554
	‏XP_006723762 NP_536721، ‏XP_006723762
	‏XP_006500617 NP_032119، ‏XP_006500617
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

GATA5‏ (GATA binding protein 5) هوَ بروتين يُشَفر بواسطة جين GATA5 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Gao X, Sedgwick T, Shi YB, Evans T (May 1998). "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation". Molecular and Cellular Biology. 18 (5): 2901–11. doi:10.1128/mcb.18.5.2901. PMC 110669. PMID 9566909.
^ "Entrez Gene: GATA5 GATA binding protein 5". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Kakita T, Hasegawa K, Morimoto T, Kaburagi S, Wada H, Sasayama S (November 1999). "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene". The Journal of Biological Chemistry. 274 (48): 34096–102. doi:10.1074/jbc.274.48.34096. PMID 10567378.
Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ (July 2001). "Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha". American Journal of Physiology. Gastrointestinal and Liver Physiology. 281 (1): G69–84. doi:10.1152/ajpgi.2001.281.1.g69. PMID 11408257.
van Wering HM, Huibregtse IL, van der Zwan SM, de Bie MS, Dowling LN, Boudreau F, Rings EH, Grand RJ, Krasinski SD (August 2002). "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter". The Journal of Biological Chemistry. 277 (31): 27659–67. doi:10.1074/jbc.M203645200. PMID 12011060.
Benchabane H, Wrana JL (September 2003). "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations". Molecular and Cellular Biology. 23 (18): 6646–61. doi:10.1128/MCB.23.18.6646-6661.2003. PMC 193708. PMID 12944489.
Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB (December 2003). "GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer". Molecular and Cellular Biology. 23 (23): 8429–39. doi:10.1128/MCB.23.23.8429-8439.2003. PMC 262684. PMID 14612389.
Divine JK, Staloch LJ, Haveri H, Jacobsen CM, Wilson DB, Heikinheimo M, Simon TC (November 2004). "GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha". American Journal of Physiology. Gastrointestinal and Liver Physiology. 287 (5): G1086–99. doi:10.1152/ajpgi.00421.2003. PMID 14715527.
Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV (December 2004). "Hypermethylation of the GATA genes in lung cancer". Clinical Cancer Research. 10 (23): 7917–24. doi:10.1158/1078-0432.CCR-04-1140. PMID 15585625.
Wakana K, Akiyama Y, Aso T, Yuasa Y (September 2006). "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis". Cancer Letters. 241 (2): 281–8. doi:10.1016/j.canlet.2005.10.039. PMID 16337738.
Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG (November 2006). "Hypermethylation of the GATA gene family in esophageal cancer". International Journal of Cancer. 119 (9): 2078–83. doi:10.1002/ijc.22092. PMID 16823849.